Emerging role of let-7 family in the pathogenesis of hematological malignancies
Fatemeh YazarlouDepartment of Medical Genetics, Tehran University of Medical Sciences, Tehran, IranSepideh KadkhodaDepartment of Medical Genetics, Tehran University of Medical Sciences, Tehran, IranSoudeh Ghafouri‐FardDepartment of Medical Genetics, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Electronic address: [email protected]
2021en
ABI
Annotatsiya
Let-7 includes a family of miRNA which are implicated in the developmental processes as well as carcinogenesis. This miRNA family has been shown to influence pathogenesis of a variety of hematological malignancies through changing expression of a number of oncogenic pathways, particularly those related with MYC. Expression of these miRNAs has been found to be different between distinct hematological malignancies or even between cytogenetically-defined subgroups of a certain malignancy. In the current review, we summarize the data regarding biogenesis, genomic locations, targets and regulatory network of this miRNA family in the context of hematological malignancies.
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