New cyclic glycolipids from <i>Silene succulenta</i> promote <i>in vitro</i> MCF-7 breast carcinoma cell apoptosis by cell cycle arrest and <i>in silico</i> mitotic Mps1/TTK inhibition
Sarah MahmoudMedicinal and Aromatic Plants Department, Desert Research Center, El-Matariya 11753, Cairo, EgyptAhmed R. HassanMedicinal and Aromatic Plants Department, Desert Research Center, El-Matariya 11753, Cairo, EgyptRawah H. ElkousyDepartment of Pharmacognosy, Faculty of Pharmacy (for Girls), Al-Azhar University, Nasr City 11651, Cairo, EgyptSalwa A. Abu El WafaDepartment of Pharmacognosy, Faculty of Pharmacy (for Girls), Al-Azhar University, Nasr City 11651, Cairo, EgyptAbd-El salam I. MohammadDepartment of Pharmacognosy, Faculty of Pharmacy (for Boys), Al-Azhar University, Nasr City 13129, Cairo, Egypt
2023en
ABI
Annotatsiya
S. succulenta may be effective in the treatment of breast cancer (MCF-7). In addition, these findings suggest that the isolated new cyclic glycolipids using a bioactive-guided approach can be used as potential antitumour breast cancer agents.
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