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MicroRNA‐132 regulates recognition memory and synaptic plasticity in the perirhinal cortex

Helen L. ScottHenry Wellcome Laboratories for Integrative Neuroscience & Endocrinology & MRC Centre for Synaptic Plasticity, Dorothy Hodgkin Building, University of Bristol, Whitson Street, Bristol BS1 3NY, UK. [email protected]Francesco TamagniniSchool of Physiology and Pharmacology & MRC Centre for Synaptic Plasticity, School of Medical Sciences, University of Bristol, University Walk, Bristol, UKKatherine E. NarduzzoSchool of Physiology and Pharmacology & MRC Centre for Synaptic Plasticity, School of Medical Sciences, University of Bristol, University Walk, Bristol, UKJoanna HowarthHenry Wellcome Laboratories for Integrative Neuroscience & Endocrinology & MRC Centre for Synaptic Plasticity, Dorothy Hodgkin Building, University of Bristol, Whitson Street, Bristol BS1 3NY, UKYoun‐Bok LeeHenry Wellcome Laboratories for Integrative Neuroscience & Endocrinology & MRC Centre for Synaptic Plasticity, Dorothy Hodgkin Building, University of Bristol, Whitson Street, Bristol BS1 3NY, UKLiang‐Fong WongHenry Wellcome Laboratories for Integrative Neuroscience & Endocrinology & MRC Centre for Synaptic Plasticity, Dorothy Hodgkin Building, University of Bristol, Whitson Street, Bristol BS1 3NY, UKMalcolm W. BrownSchool of Physiology and Pharmacology & MRC Centre for Synaptic Plasticity, School of Medical Sciences, University of Bristol, University Walk, Bristol, UKElizabeth C. WarburtonSchool of Physiology and Pharmacology & MRC Centre for Synaptic Plasticity, School of Medical Sciences, University of Bristol, University Walk, Bristol, UKZafar I. BashirUniversity of Bologna, Via Zamboni, Bologna, ItalyJames B. UneyHenry Wellcome Laboratories for Integrative Neuroscience & Endocrinology & MRC Centre for Synaptic Plasticity, Dorothy Hodgkin Building, University of Bristol, Whitson Street, Bristol BS1 3NY, UK

2012en

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Annotatsiya

Evidence suggests that the acquisition of recognition memory depends upon CREB-dependent long-lasting changes in synaptic plasticity in the perirhinal cortex.The CREB-responsive microRNA miR-132 has been shown to regulate synaptic transmission and we set out to investigate a role for this microRNA in recognition memory and its underlying plasticity mechanisms. To this end we mediated the specific overexpression of miR-132 selectively in the rat perirhinal cortex and demonstrated impairment in short-term recognition memory. This functional deficit was associated with a reduction in both long-term depression and long-term potentiation. These results confirm that microRNAs are key coordinators of the intracellular pathways that mediate experience-dependent changes in the brain. In addition, these results demonstrate a role for miR-132 in the neuronal mechanisms underlying the formation of short-term recognition memory.

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DOI: 10.1111/j.1460-9568.2012.08220.x

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