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Sesquiterpene Lactones from the Roots of <i>Ferula varia</i> and Their Cytotoxic Activity

Kyoko SuzukiGraduate School of Pharmaceutical Sciences, University of Tokushima, Shomachi 1-78, Tokushima, 770-8505, Japan, Graduate School of Pharmaceutical Sciences, Kyoto University, Yoshida, Sakyo-ku, Kyoto, 606–8501, Japan, Faculty of Integrated Arts and Sciences, University of Tokushima, Minamijyosanjimacyou 1-1, Tokushima, 770-8502, Japan, Institute of Botany and Botanical Garden, F. Khodzhaev, st. 32, 700143, Tashkent, Uzbekistan, and Faculty of Pharmaceutical Sciences, Niigata University of Pharmacy andMamoru OkasakaGraduate School of Pharmaceutical Sciences, University of Tokushima, Shomachi 1-78, Tokushima, 770-8505, Japan, Graduate School of Pharmaceutical Sciences, Kyoto University, Yoshida, Sakyo-ku, Kyoto, 606–8501, Japan, Faculty of Integrated Arts and Sciences, University of Tokushima, Minamijyosanjimacyou 1-1, Tokushima, 770-8502, Japan, Institute of Botany and Botanical Garden, F. Khodzhaev, st. 32, 700143, Tashkent, Uzbekistan, and Faculty of Pharmaceutical Sciences, Niigata University of Pharmacy andYoshiki KashiwadaGraduate School of Pharmaceutical Sciences, University of Tokushima, Shomachi 1-78, Tokushima, 770-8505, Japan, Graduate School of Pharmaceutical Sciences, Kyoto University, Yoshida, Sakyo-ku, Kyoto, 606–8501, Japan, Faculty of Integrated Arts and Sciences, University of Tokushima, Minamijyosanjimacyou 1-1, Tokushima, 770-8502, Japan, Institute of Botany and Botanical Garden, F. Khodzhaev, st. 32, 700143, Tashkent, Uzbekistan, and Faculty of Pharmaceutical Sciences, Niigata University of Pharmacy andYoshihisa TakaishiGraduate School of Pharmaceutical Sciences, University of Tokushima, Shomachi 1-78, Tokushima, 770-8505, Japan, Graduate School of Pharmaceutical Sciences, Kyoto University, Yoshida, Sakyo-ku, Kyoto, 606–8501, Japan, Faculty of Integrated Arts and Sciences, University of Tokushima, Minamijyosanjimacyou 1-1, Tokushima, 770-8502, Japan, Institute of Botany and Botanical Garden, F. Khodzhaev, st. 32, 700143, Tashkent, Uzbekistan, and Faculty of Pharmaceutical Sciences, Niigata University of Pharmacy andGisho HondaGraduate School of Pharmaceutical Sciences, University of Tokushima, Shomachi 1-78, Tokushima, 770-8505, Japan, Graduate School of Pharmaceutical Sciences, Kyoto University, Yoshida, Sakyo-ku, Kyoto, 606–8501, Japan, Faculty of Integrated Arts and Sciences, University of Tokushima, Minamijyosanjimacyou 1-1, Tokushima, 770-8502, Japan, Institute of Botany and Botanical Garden, F. Khodzhaev, st. 32, 700143, Tashkent, Uzbekistan, and Faculty of Pharmaceutical Sciences, Niigata University of Pharmacy andMichiho ItoGraduate School of Pharmaceutical Sciences, University of Tokushima, Shomachi 1-78, Tokushima, 770-8505, Japan, Graduate School of Pharmaceutical Sciences, Kyoto University, Yoshida, Sakyo-ku, Kyoto, 606–8501, Japan, Faculty of Integrated Arts and Sciences, University of Tokushima, Minamijyosanjimacyou 1-1, Tokushima, 770-8502, Japan, Institute of Botany and Botanical Garden, F. Khodzhaev, st. 32, 700143, Tashkent, Uzbekistan, and Faculty of Pharmaceutical Sciences, Niigata University of Pharmacy andYoshio TakedaGraduate School of Pharmaceutical Sciences, University of Tokushima, Shomachi 1-78, Tokushima, 770-8505, Japan, Graduate School of Pharmaceutical Sciences, Kyoto University, Yoshida, Sakyo-ku, Kyoto, 606–8501, Japan, Faculty of Integrated Arts and Sciences, University of Tokushima, Minamijyosanjimacyou 1-1, Tokushima, 770-8502, Japan, Institute of Botany and Botanical Garden, F. Khodzhaev, st. 32, 700143, Tashkent, Uzbekistan, and Faculty of Pharmaceutical Sciences, Niigata University of Pharmacy andOlimjon K. KodzhimatovGraduate School of Pharmaceutical Sciences, University of Tokushima, Shomachi 1-78, Tokushima, 770-8505, Japan, Graduate School of Pharmaceutical Sciences, Kyoto University, Yoshida, Sakyo-ku, Kyoto, 606–8501, Japan, Faculty of Integrated Arts and Sciences, University of Tokushima, Minamijyosanjimacyou 1-1, Tokushima, 770-8502, Japan, Institute of Botany and Botanical Garden, F. Khodzhaev, st. 32, 700143, Tashkent, Uzbekistan, and Faculty of Pharmaceutical Sciences, Niigata University of Pharmacy andOzodbek AshurmetovGraduate School of Pharmaceutical Sciences, University of Tokushima, Shomachi 1-78, Tokushima, 770-8505, Japan, Graduate School of Pharmaceutical Sciences, Kyoto University, Yoshida, Sakyo-ku, Kyoto, 606–8501, Japan, Faculty of Integrated Arts and Sciences, University of Tokushima, Minamijyosanjimacyou 1-1, Tokushima, 770-8502, Japan, Institute of Botany and Botanical Garden, F. Khodzhaev, st. 32, 700143, Tashkent, Uzbekistan, and Faculty of Pharmaceutical Sciences, Niigata University of Pharmacy andMichiko SekiyaGraduate School of Pharmaceutical Sciences, University of Tokushima, Shomachi 1-78, Tokushima, 770-8505, Japan, Graduate School of Pharmaceutical Sciences, Kyoto University, Yoshida, Sakyo-ku, Kyoto, 606–8501, Japan, Faculty of Integrated Arts and Sciences, University of Tokushima, Minamijyosanjimacyou 1-1, Tokushima, 770-8502, Japan, Institute of Botany and Botanical Garden, F. Khodzhaev, st. 32, 700143, Tashkent, Uzbekistan, and Faculty of Pharmaceutical Sciences, Niigata University of Pharmacy andYasumasa IkeshiroGraduate School of Pharmaceutical Sciences, University of Tokushima, Shomachi 1-78, Tokushima, 770-8505, Japan, Graduate School of Pharmaceutical Sciences, Kyoto University, Yoshida, Sakyo-ku, Kyoto, 606–8501, Japan, Faculty of Integrated Arts and Sciences, University of Tokushima, Minamijyosanjimacyou 1-1, Tokushima, 770-8502, Japan, Institute of Botany and Botanical Garden, F. Khodzhaev, st. 32, 700143, Tashkent, Uzbekistan, and Faculty of Pharmaceutical Sciences, Niigata University of Pharmacy and

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Annotatsiya

The ethyl acetate-soluble fraction from a MeOH extract of the roots of Ferula varia gave six new sesquiterpene lactones (1-6) and five known sesquiterpenes (7-11). Their structures were established on the basis of spectroscopic evidence. The cytotoxic activities of 1-11 were evaluated against selected human cancer cell lines. Compound 4 showed significant selective cytotoxicity against multidrug-resistant cancer cells (KB-C2). The cytotoxicities of compounds 1, 3, 5, 8, and 11 against KB-C2 cells were enhanced in the presence of nontoxic concentrations of colchicine.

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Identifikatorlar

DOI: 10.1021/np0703996

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