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Cancer stem cells: a target for overcoming therapeutic resistance and relapse

Shuo ZhangDepartment of Radiation Oncology, Radiation Oncology Key Laboratory of Sichuan Province, Sichuan Clinical Research Center for Cancer, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, Affiliated Cancer Hospital of University of Electronic Science and Technology of China, Chengdu 610042, ChinaRui YangDepartment of Ultrasound in Medicine, Chengdu Wenjiang District People's Hospital, Chengdu 611130, ChinaYujie OuyangAcupuncture and Massage College, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, ChinaYang ShenDepartment of Oncology & Cancer Institute, Sichuan Academy of Medical Sciences and Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu 610072, ChinaLanlin HuDepartment of Oncology & Cancer Institute, Sichuan Academy of Medical Sciences and Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu 610072, ChinaChuan XuDepartment of Oncology & Cancer Institute, Sichuan Academy of Medical Sciences and Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu 610072, China

2024en

ABI

Annotatsiya

Cancer stem cells (CSCs) are a small subset of cells in cancers that are thought to initiate tumorous transformation and promote metastasis, recurrence, and resistance to treatment. Growing evidence has revealed the existence of CSCs in various types of cancers and suggested that CSCs differentiate into diverse lineage cells that contribute to tumor progression. We may be able to overcome the limitations of cancer treatment with a comprehensive understanding of the biological features and mechanisms underlying therapeutic resistance in CSCs. This review provides an overview of the properties, biomarkers, and mechanisms of resistance shown by CSCs. Recent findings on metabolic features, especially fatty acid metabolism and ferroptosis in CSCs, are highlighted, along with promising targeting strategies. Targeting CSCs is a potential treatment plan to conquer cancer and prevent resistance and relapse in cancer treatment.

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Identifikatorlar

DOI: 10.20892/j.issn.2095-3941.2023.0333

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