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A Comprehensive Analysis and Anti-Cancer Activities of Quercetin in ROS-Mediated Cancer and Cancer Stem Cells

Partha BiswasABEx Bio-Research Center, East Azampur, Dhaka 1230, BangladeshDipta DeyBiochemistry and Molecular Biology Department, Life Science Faculty, Bangabandhu Sheikh Mujibur Rahman Science and Technology University, Gopalgonj 8100, BangladeshPolash Kumar BiswasABEx Bio-Research Center, East Azampur, Dhaka 1230, BangladeshTanjim Ishraq RahamanDepartment of Biotechnology and Genetic Engineering, Faculty of Life Science, Bangabandhu Sheikh Mujibur Rahman Science and Technology University, Gopalganj 8100, BangladeshShuvo SahaAnwar ParvezDepartment of Pharmacy, Faculty of Allied Health Sciences, Daffodil International University, Dhaka 1207, BangladeshDhrubo Ahmed KhanNusrat Jahan LilyDepartment of Microbiology, Stamford University, Dhaka 1217, BangladeshKonka SahaShaheed Taj Uddin Ahmad Medical College, Gazipu 1712, BangladeshMd SohelDepartment of Biochemistry and Molecular Biology, Faculty of life Science, Mawlana Bhashani Science and Technology University, Santosh, Tangail 1902, BangladeshMohammad Mehedi HasanDepartment of Biochemistry and Molecular Biology, Faculty of life Science, Mawlana Bhashani Science and Technology University, Santosh, Tangail 1902, BangladeshSalauddin Al AzadSchool of Biotechnology, Jiangnan University, 1800, Lihu Avenue, Wuxi 214122, ChinaShabana BibiDepartment of Bioscience, Shifa Tameer-e-Millat University, Islamabad 44000, PakistanMd. Nazmul HasanMohammed RahmatullahDepartment of Biotechnology Genetic Engineering, University of Development Alternative, Lalmatia, Dhaka 1207, BangladeshJaemoo ChunKM Convergence Research Division, Korea Institute of Oriental Medicine, Daejeon 34054, KoreaMd. Ataur RahmanDepartment of Pathology, College of Korean Medicine, Kyung Hee University, Seoul 02447, KoreaBonglee KimDepartment of Pathology, College of Korean Medicine, Kyung Hee University, Seoul 02447, Korea

2022en

ABI

Annotatsiya

Reactive oxygen species (ROS) induce carcinogenesis by causing genetic mutations, activating oncogenes, and increasing oxidative stress, all of which affect cell proliferation, survival, and apoptosis. When compared to normal cells, cancer cells have higher levels of ROS, and they are responsible for the maintenance of the cancer phenotype; this unique feature in cancer cells may, therefore, be exploited for targeted therapy. Quercetin (QC), a plant-derived bioflavonoid, is known for its ROS scavenging properties and was recently discovered to have various antitumor properties in a variety of solid tumors. Adaptive stress responses may be induced by persistent ROS stress, allowing cancer cells to survive with high levels of ROS while maintaining cellular viability. However, large amounts of ROS make cancer cells extremely susceptible to quercetin, one of the most available dietary flavonoids. Because of the molecular and metabolic distinctions between malignant and normal cells, targeting ROS metabolism might help overcome medication resistance and achieve therapeutic selectivity while having little or no effect on normal cells. The powerful bioactivity and modulatory role of quercetin has prompted extensive research into the chemical, which has identified a number of pathways that potentially work together to prevent cancer, alongside, QC has a great number of evidences to use as a therapeutic agent in cancer stem cells. This current study has broadly demonstrated the function-mechanistic relationship of quercetin and how it regulates ROS generation to kill cancer and cancer stem cells. Here, we have revealed the regulation and production of ROS in normal cells and cancer cells with a certain signaling mechanism. We demonstrated the specific molecular mechanisms of quercetin including MAPK/ERK1/2, p53, JAK/STAT and TRAIL, AMPKα1/ASK1/p38, RAGE/PI3K/AKT/mTOR axis, HMGB1 and NF-κB, Nrf2-induced signaling pathways and certain cell cycle arrest in cancer cell death, and how they regulate the specific cancer signaling pathways as long-searched cancer therapeutics.

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DOI: 10.3390/ijms231911746

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