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Tumor Microenvironment-Responsive MnO<sub><i>x</i></sub>-Mesoporous Carbon Nanoparticles for Enhanced Chemodynamic Synergistic Antitumor Therapy

Rongrong ZhangChangchun University of Science and TechnologyTingting WangChangchun University of Science and TechnologyHaiyu ShenChangchun University of Science and TechnologyXue ZhouFaculty of Chemistry, Northeast Normal University, 5268 Renmin Street, Changchun, Jilin 130024, P. R. ChinaQinghe HanRadiology DepartmentLu LiFaculty of Chemistry, Northeast Normal University, 5268 Renmin Street, Changchun, Jilin 130024, P. R. ChinaLingyu ZhangFaculty of Chemistry, Northeast Normal University, 5268 Renmin Street, Changchun, Jilin 130024, P. R. ChinaChungang WangFaculty of Chemistry, Northeast Normal University, 5268 Renmin Street, Changchun, Jilin 130024, P. R. ChinaXiangting DongChangchun University of Science and Technology

2025en

ABI

Annotatsiya

Developing nanomedicines with simultaneous diagnosis and treatment functions is a promising therapeutic strategy for cancer therapy. Herein, multifunctional manganese oxide-mesoporous carbon nanoparticles (MnOx-MCN NPs) were designed for magnetic resonance imaging (MRI)-guided chemotherapy, photothermal therapy (PTT), and chemodynamic therapy (CDT). The excellent photothermal conversion efficiency (44.2%) and outstanding fenton-like catalytic activity endowed MnOx-MCN NPs with a PTT/CDT synergistic therapy. Furthermore, with their unique mesoporous structure, MnOx-MCN NPs can also act as a drug delivery carrier for encapsulating chemotherapy agent doxorubicin (DOX). The mild acid tumor microenvironment (TME) and near-infrared (NIR) heat induced the release of DOX. In addition, the NIR laser enhanced the CDT efficiency of MnOx-MCN NPs, thus generating a synergistic chemotherapy/PTT/CDT effect. Extracellular experiments demonstrated that the heat generated by laser irradiation of MnOx-MCN NPs could encourage the generation of •OH. More importantly, MnOx-MCN NPs displayed a superior synergistic anticancer efficiency both in vitro and in vivo. Such elaborately synthesized nanomaterial provides a paradigm for the design of other multifunction nanoagents.

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Identifikatorlar

DOI: 10.1021/acsanm.4c06257

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