Emerging roles of lncRNA in cancer and therapeutic opportunities.
Mingchun JiangDepartment of Cell Biology, Zhejiang University School of Medicine Hangzhou 310058, Zhejiang, ChinaJiaojiao NiDepartment of Cell Biology, Zhejiang University School of Medicine Hangzhou 310058, Zhejiang, ChinaWenyu CuiDepartment of Cell Biology, Zhejiang University School of Medicine Hangzhou 310058, Zhejiang, ChinaBoya WangDepartment of Pharmacy, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine Hangzhou 310016, Zhejiang, ChinaWei ZhuoDepartment of Cell Biology, Zhejiang University School of Medicine Hangzhou 310058, Zhejiang, China
2019en
ABI
Annotatsiya
Cancer is difficult to cure due to frequent metastasis, and developing effective therapeutic approaches to treat cancer is urgently important. Long non-coding RNAs (lncRNAs) have diverse roles in regulating gene expression at both the transcriptional and translational levels and have been reported to be involved in tumorigenesis and tumor metastasis. In this article, we review the emerging roles of lncRNAs in cancer, especially in cancer immunity, cancer metabolism and cancer metastasis. We also discuss the use of novel technologies, such as antisense oligonucleotides, CRISPR-Cas9 and nanomedicines, to target lncRNAs and thus control cancers.
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