Electrochemical Dearomative Dicarboxylation of Heterocycles with Highly Negative Reduction Potentials
Yong YouInstitute for Chemical Reaction Design and Discovery (WPI-ICReDD), Hokkaido University, Kita 21, Nishi 10, Kita-ku, Sapporo, Hokkaido 001-0021, JapanWataru KannaDepartment of Chemistry, Faculty of Science, Hokkaido University, Kita 10, Nishi
8, Kita-ku, Sapporo, Hokkaido 060-0810, JapanHideaki TakanoInstitute for Chemical Reaction Design and Discovery (WPI-ICReDD), Hokkaido University, Kita 21, Nishi 10, Kita-ku, Sapporo, Hokkaido 001-0021, JapanHiroki HayashiInstitute for Chemical Reaction Design and Discovery (WPI-ICReDD), Hokkaido University, Kita 21, Nishi 10, Kita-ku, Sapporo, Hokkaido 001-0021, JapanSatoshi MaedaDepartment of Chemistry, Faculty of Science, Hokkaido University, Kita 10, Nishi
8, Kita-ku, Sapporo, Hokkaido 060-0810, JapanTsuyoshi MitaInstitute for Chemical Reaction Design and Discovery (WPI-ICReDD), Hokkaido University, Kita 21, Nishi 10, Kita-ku, Sapporo, Hokkaido 001-0021, Japan
2022en
ABI
Annotatsiya
-Boc-pyrazole, also exhibit reduction potentials more positive than -3 V and served as effective substrates for such dicarboxylations. The dicarboxylated products thus obtained can be derivatized into useful synthetic intermediates for biologically active compounds in few steps. We also show how the dearomative monocarboxylation can be achieved selectively by choice of the electrolyte, solvent, and protic additive; this strategy was then applied to the synthesis of an octahydroindole-2-carboxylic acid (Oic) derivative, which is a useful proline analogue.
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