Cancer stem cell metabolism
Maria Peiris‐PagèsThe Breast Cancer Now Research Unit, Institute of Cancer Sciences, CRUK Manchester Institute, Paterson Building, University of Manchester, Manchester, UKUbaldo Martinez‐OutschoornThe Sidney Kimmel Cancer Center, Philadelphia, PA, USARichard G. PestellThe Sidney Kimmel Cancer Center, Philadelphia, PA, USAFederica SotgiaThe Breast Cancer Now Research Unit, Institute of Cancer Sciences, CRUK Manchester Institute, Paterson Building, University of Manchester, Manchester, UK. [email protected]Michael P. LisantiThe Breast Cancer Now Research Unit, Institute of Cancer Sciences, CRUK Manchester Institute, Paterson Building, University of Manchester, Manchester, UK. [email protected]
2016en
ABI
Annotatsiya
Cancer is now viewed as a stem cell disease. There is still no consensus on the metabolic characteristics of cancer stem cells, with several studies indicating that they are mainly glycolytic and others pointing instead to mitochondrial metabolism as their principal source of energy. Cancer stem cells also seem to adapt their metabolism to microenvironmental changes by conveniently shifting energy production from one pathway to another, or by acquiring intermediate metabolic phenotypes. Determining the role of cancer stem cell metabolism in carcinogenesis has become a major focus in cancer research, and substantial efforts are conducted towards discovering clinical targets.
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