A uniform system for microRNA annotation
Victor AmbrosDartmouth Medical School Department of Genetics, Hanover, New Hampshire 03755, USA. [email protected]Bonnie BartelDepartment of Biochemistry and Cell Biology, Rice University, Houston, Texas 77005, USADavid P. BartelWhitehead Institute for Biomedical Research, Massachusetts Institute of Technology, Department of Biology, Cambridge, Massachusetts 02139, USAChristopher B. BurgeMassachusetts Institute of Technology, Department of Biology, Cambridge, Massachusetts 02142, USAJames C. CarringtonCenter for Gene Research and Biotechnology, and Department of Botany and Plant Pathology, Oregon State University, Corvallis, Oregon 97331, USAXuemei ChenWaksman Institute, Rutgers University, Piscataway, New Jersey 08854, USAGideon DreyfussHoward Hughes Medical Institute and Department of Biochemistry & Biophysics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104-6148, USASean R. EddyHoward Hughes Medical Institute, Washington University Department of Genetics, Saint Louis, Missouri 63110, USASam Griffiths‐JonesCambridge Center, Cambridge, MA 02142, USA;Mhairi MarshallCambridge Center, Cambridge, MA 02142, USA;Marjori MatzkeInstitute of Molecular Biology, Austrian Academy of Sciences, A-5020 Salzburg, AustriaGary RuvkunDepartment of Genetics, Harvard Medical School, and Department of Molecular Biology, Massachusetts General Hospital, Boston, Massachusetts 02114, USAThomas TuschlMax-Planck-Institute for Biophysical Chemistry, Department of Cellular Biochemistry, Go ttingen, Germany
2003en
ABI
Annotatsiya
MicroRNAs (miRNAs) are small noncoding RNA gene products about 22 nt long that are processed by Dicer from precursors with a characteristic hairpin secondary structure. Guidelines are presented for the identification and annotation of new miRNAs from diverse organisms, particularly so that miRNAs can be reliably distinguished from other RNAs such as small interfering RNAs. We describe specific criteria for the experimental verification of miRNAs, and conventions for naming miRNAs and miRNA genes. Finally, an online clearinghouse for miRNA gene name assignments is provided by the Rfam database of RNA families.
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