Diphyllin Acetylapioside, A 5-Lipoxygenase Inhibitor from Haplophyllum hispanicum
José M. PrietoDepartament de Farmacologia. Universitat de València. Burjassot, SpainRosa M. GinerDepartament de Farmacologia. Universitat de València. Burjassot, SpainM. Carmen RecioDepartament de Farmacologia. Universitat de València. Burjassot, SpainGuillermo SchinellaCátedra de Farmacología. Facultat de Ciencias Médicas. Universidad Nacional de La Plata; La Plata, ArgentinaSalvador MáñezDepartament de Farmacologia. Universitat de València. Burjassot, SpainJosé Luis Rı́osDepartament de Farmacologia. Universitat de València. Burjassot, Spain
2002en
ABI
Annotatsiya
The topical anti-inflammatory activity of Haplophyllum hispanicum Spach is due to the presence of arylnaphthalene-type lignans acting as 5-lipoxygenase (5-LOX) inhibitors. The effects of the methanolic extract of this species on cellular systems have been determined by HPLC-DAD analysis. Diphyllin acetylapioside proved to be the main lignan endowed with 5-LOX inhibitory activity.
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