Two New Monoterpene Glycosides and Trypanocidal Terpenoids from Dracocephalum kotschyi
Soodabeh SaeidniaDepartment of Pharmacy, Faculty of Pharmacy, Medical Sciences University of MazandaranAhmad Reza GohariDepartment of Pharmacy, Faculty of Pharmacy, Medical Sciences University of MazandaranNahoko UchiyamaGraduate School of Pharmaceutical Sciences, Kyoto UniversityMichiho ItoGraduate School of Pharmaceutical Sciences, Kyoto UniversityGisho HondaGraduate School of Pharmaceutical Sciences, Kyoto UniversityFumiyuki KiuchiTsukuba Medicinal Plant Research Station, National Institute of Health Sciences, Ministry of Health, Labor and Welfare, Japan
2004en
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Annotatsiya
From the whole plant of Dracocephalum kotschyi BOISS., two new monoterpene glycosides (9, 10), together with seven known terpenoids and a phytosterol (1-8), were isolated. Their structures were determined to be limonen-10-al (1), geranial (2), neral (3), beta-sitosterol (4), oleanolic acid (5), ursolic acid (6), p-mentha-8-en-1,2-diol (7), colosolic acid (8), limonen-10-ol 10-O-beta-D-glucopyranoside (9), and limonen-10-ol 10-O-beta-D-glucopyranosyl-(1-->2)-beta-D-glucopyranoside (10). Compounds 1 (3.1 microM), 2 (3.1 microM), 3 (3.1 microM), 5 (6.2 microM), 6 (6.2 microM), and 8 (6.2 microM) were effective against epimastigotes of Trypanosoma cruzi.
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