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The anti-inflammatory natural product parthenolide from the medicinal herb Feverfew directly binds to and inhibits IκB kinase

Benjamin H. KwokDepartment of Molecular, Cellular, and Developmental Biology, Yale University, New Haven, CT 06520-8103, USABrian D. KohDepartment of Molecular, Cellular, and Developmental Biology, Yale University, New Haven, CT 06520-8103, USAMacKevin NdubuisiDepartment of Molecular, Cellular, and Developmental Biology, Yale University, New Haven, CT 06520-8103, USAMikael ElofssonDepartment of Molecular, Cellular, and Developmental Biology, Yale University, New Haven, CT 06520-8103, USACraig M. CrewsDepartment of Pharmacology, Yale University, New Haven, CT 06520-8103, USA
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