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Chemical Constituents and Evaluation of Antimicrobial and Cytotoxic Activities of<i>Kielmeyera coriacea</i>Mart. &amp; Zucc. Essential Oils

Carla de M. MartinsGoian Federal Institute, Campus Morrinhos, 75650-000 Morrinhos, GO, BrazilEvandro A. NascimentoNucleus of Research in Natural Products, Chemistry Institute, Federal University of Uberlândia, 38400-902 Uberlândia, MG, BrazilSérgio A.L. MoraisNucleus of Research in Natural Products, Chemistry Institute, Federal University of Uberlândia, 38400-902 Uberlândia, MG, BrazilAlberto de OliveiraNucleus of Research in Natural Products, Chemistry Institute, Federal University of Uberlândia, 38400-902 Uberlândia, MG, BrazilRoberto ChangNucleus of Research in Natural Products, Chemistry Institute, Federal University of Uberlândia, 38400-902 Uberlândia, MG, BrazilLuís Carlos Scalon CunhaNucleus of Research in Natural Products, Chemistry Institute, Federal University of Uberlândia, 38400-902 Uberlândia, MG, BrazilMário Machado MartinsNucleus of Research in Natural Products, Chemistry Institute, Federal University of Uberlândia, 38400-902 Uberlândia, MG, BrazilCarlos Henrique Gomes MartinsNucleus of Research in Sciences and Technology, Laboratory of Research in Applied Microbiology, University of Franca, 14404-600 Franca, SP, BrazilThaís da Silva MoraesNucleus of Research in Sciences and Technology, Laboratory of Research in Applied Microbiology, University of Franca, 14404-600 Franca, SP, BrazilPaulla Vieira RodriguesInstitute of Biomedical Sciences, Laboratory of Trypanosomatids, Federal University of Uberlândia, 38400-902 Uberlândia, MG, BrazilCláudio Vieira da SilvaInstitute of Biomedical Sciences, Laboratory of Trypanosomatids, Federal University of Uberlândia, 38400-902 Uberlândia, MG, BrazilF. AquinoNucleus of Research in Natural Products, Chemistry Institute, Federal University of Uberlândia, 38400-902 Uberlândia, MG, Brazil
2015en
ABI

Annotatsiya

Many essential oils (EOs) of different plant species possess interesting antimicrobial effects on buccal microorganisms and cytotoxic properties. EOs of Kielmeyera coriacea Mart. & Zucc. were analyzed by gas chromatography coupled to mass spectrometry (GC-MS). The EO from leaves is rich in sesquiterpenes hydrocarbons and oxygenated sesquiterpenes. The three major compounds identified were germacrene-D (24.2%), (E)-caryophyllene (15.5%), and bicyclogermacrene (11.6%). The inner bark EO is composed mainly of sesquiterpenes hydrocarbons and the major components are alpha-copaene (14.9%) and alpha-(E)-bergamotene (13.0%). The outer bark EO is composed mainly of oxygenated sesquiterpenes and long-chain alkanes, and the major components are alpha-eudesmol (4.2%) and nonacosane (5.8%). The wood EO is mainly composed of long-chain alkanes and fatty acids, and the major components are nonacosane (9.7%) and palmitic acid (16.2%). The inner bark EO showed the strongest antimicrobial activity against the anaerobic bacteria Prevotella nigrescens (minimum inhibitory concentration-MIC of 50 µg mL(-1)). The outer bark and wood EOs showed MICs of 100 µg mL(-1) for all aerobic microorganisms tested. The EOs presented low toxicity to Vero cells. These results suggest that K. coriacea, a Brazilian plant, provide initial evidence of a new and alternative source of substances with medicinal interest.

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DOI
10.1155/2015/842047

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