Hidden Killers: Human Fungal Infections
Gordon D. BrownAberdeen Fungal Group, Institute of Medical Sciences, University of Aberdeen, Aberdeen AB25 2ZD, UKDavid W. DenningNational Aspergillosis Centre Education and Research Centre, University Hospital of South Manchester, Manchester M23 9LT, UKNeil A. R. GowAberdeen Fungal Group, Institute of Medical Sciences, University of Aberdeen, Aberdeen AB25 2ZD, UKStuart M. LevitzDepartment of Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USAMihai G. NeteaDepartment of Internal Medicine and the Nijmegen Institute for Infection, Inflammation, and Immunity, Radboud University Nijmegen, Nijmegen 6500HB, NetherlandsTheodore C. WhiteSchool of Biological Sciences, University of Missouri-Kansas City, Kansas City, MO 64110, USA
2012en
ABI
Annotatsiya
Although fungal infections contribute substantially to human morbidity and mortality, the impact of these diseases on human health is not widely appreciated. Moreover, despite the urgent need for efficient diagnostic tests and safe and effective new drugs and vaccines, research into the pathophysiology of human fungal infections lags behind that of diseases caused by other pathogens. In this Review, we highlight the importance of fungi as human pathogens and discuss the challenges we face in combating the devastating invasive infections caused by these microorganisms, in particular in immunocompromised individuals.
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