Sharh maqola

Metal enhanced fluorescence (MEF) for biosensors: General approaches and a review of recent developments

Yoon JeongYun-Min KookDepartment of Chemical and Biomolecular Engineering, Yonsei University, Seoul, Republic of KoreaKangwon LeeProgram in Nanoscience and Technology, Graduate School of Convergence Science and Technology, Seoul National University, Seoul, Republic of Korea; Advanced Institutes of Convergence Technology, Gyeonggi-do, Republic of Korea. Electronic address: [email protected]Won‐Gun KohDepartment of Chemical and Biomolecular Engineering, Yonsei University, Seoul, Republic of Korea. Electronic address: [email protected]

2018en

ABI

Annotatsiya

Fluorescence-based biosensor platforms have been intensively investigated not only to increase the sensitivity but also to improve the performance of biosensors. By exploiting metal from the macroscopic down to the nanoscopic surface, various architectures have been devised to manipulate fluorescence signals (enhancement, quenching) within near-optical fields. The interaction of a metallic surface with proximal fluorophores (in the range of 5-90 nm) has beneficial effects on optical properties such as an increased quantum yield, improved photostability and a reduced lifetime of fluorophores. This phenomenon called metal-enhanced fluorescence (MEF) has been extensively used in biosensory applications. However, their applications for biological analysis practically remain challenging in biological microenvironments. Therefore, this review primarily provides a general overview of MEF biosensor systems from the basic mechanism to state-of-the-art biological applications. The review also covers the pros and cons of MEF biosensor as well as discussions about further directions in biological perspectives.

Hali tarjima qilinmagan

Identifikatorlar

DOI: 10.1016/j.bios.2018.04.007

Iqtiboslar va manbalar

2 ta iqtibos0 ta foydalanilgan manba

Koʻrsatkichlar — AkademScholar