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Chromone and isocoumarin derivatives from the endophytic fungus <i>Xylomelasma</i> sp. Samif07, and their antibacterial and antioxidant activities

Daowan LaiDepartment of Plant Pathology, College of Plant Protection, China Agricultural University, Beijing, ChinaJing LiDepartment of Plant Pathology, College of Plant Protection, China Agricultural University, Beijing, ChinaSiji ZhaoDepartment of Plant Pathology, College of Plant Protection, China Agricultural University, Beijing, ChinaGangxu GuDepartment of Plant Pathology, College of Plant Protection, China Agricultural University, Beijing, ChinaXiao Yang GongDepartment of Plant Pathology, College of Plant Protection, China Agricultural University, Beijing, ChinaPeter ProkschInstitute of Pharmaceutical Biology and Biotechnology, Heinrich-Heine University, DüSseldorf, GermanyLigang ZhouDepartment of Plant Pathology, College of Plant Protection, China Agricultural University, Beijing, China

2019en

ABI

Annotatsiya

Five chromone derivatives, including 2,6-dimethyl-5-methoxyl-7-hydroxylchromone (1), 6-hydroxymethyleugenin (2), 6-methoxymethyleugenin (3), chaetoquadrin D (4), and isoeugenitol (5), and three isocoumarin congeners, namely diaporthin (6), 8-hydroxy-6-methoxy-3-methylisocoumarin (7), and 6-methoxymellein (8), were isolated from the culture of the endophytic fungus Xylomelasma sp. Samif07 derived from the medicinal plant Salvia miltiorrhiza Bunge. Among them, compound 1 was a new natural product. Their structures were determined by spectroscopic methods and comparison with the literature. The isolated compounds were evaluated for their antibacterial and antioxidant activities. Compound 5 showed notable antitubercular activity against Mycobacterium tuberculosis with MIC value of 10.31 µg/mL, while compounds 1–3, and 5–7 displayed inhibitory activities against the other bacteria with MIC range of 25 ∼ 100 µg/mL. Meanwhile, compound 6 showed potent hydroxyl radical-scavenging activity with EC50 value of 15.1 µg/mL, while compounds 5–7 showed certain ferric reducing ability.

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Identifikatorlar

DOI: 10.1080/14786419.2019.1696333

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