Induction of Double-strand Breaks Following Neutron Capture by DNA-bound <sup>157</sup> Gd
Roger F. MartinMolecular Science Group, Peter MacCallum Cancer Institute, 481 Lt. Lonsdale Street, Melbourne, Victoria, AustraliaG. D'CUNHAAustralian Nuclear Science and Technology Organization, Lucas Heights Research Laboratories, New Illawarra Road, Menai, NSW 2234, AustraliaMarshall PardeeMolecular Science Group, Peter MacCallum Cancer Institute, 481 Lt. Lonsdale Street, Melbourne, Victoria, AustraliaBarry AllenAustralian Nuclear Science and Technology Organization, Lucas Heights Research Laboratories, New Illawarra Road, Menai, NSW 2234, Australia
1988en
ABI
Annotatsiya
Irradiation of plasmid DNA/Gd3+ mixtures with thermal neutrons induces DNA double-strand breaks (dsb). However, the extent of breakage is markedly reduced by sequestering the Gd3+ from DNA by addition of EDTA. Since the 157Gd neutron capture event involves some internal conversion, we suggest that the DNA dsb induction results from Auger electron emission.
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