Gene expression patterns of breast carcinomas distinguish tumor subclasses with clinical implications
Thérese SørlieDepartments of Genetics and Surgery, The Norwegian Radium Hospital, Montebello, N-0310 Oslo, Norway; Department of Genetics and Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC 27599; Departments of Health Research and Policy and Statistics, Genetics, Pathology, Surgery, and Biochemistry and Howard Hughes Medical Institute, Stanford University School of Medicine, Stanford, CA 94305; Departments of Medicine (Section of Oncology), Surgery, and BiochemicalCharles M. PerouDepartments of Genetics and Surgery, The Norwegian Radium Hospital, Montebello, N-0310 Oslo, Norway; Department of Genetics and Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC 27599; Departments of Health Research and Policy and Statistics, Genetics, Pathology, Surgery, and Biochemistry and Howard Hughes Medical Institute, Stanford University School of Medicine, Stanford, CA 94305; Departments of Medicine (Section of Oncology), Surgery, and BiochemicalRobert TibshiraniDepartments of Genetics and Surgery, The Norwegian Radium Hospital, Montebello, N-0310 Oslo, Norway; Department of Genetics and Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC 27599; Departments of Health Research and Policy and Statistics, Genetics, Pathology, Surgery, and Biochemistry and Howard Hughes Medical Institute, Stanford University School of Medicine, Stanford, CA 94305; Departments of Medicine (Section of Oncology), Surgery, and BiochemicalTurid AasDepartments of Genetics and Surgery, The Norwegian Radium Hospital, Montebello, N-0310 Oslo, Norway; Department of Genetics and Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC 27599; Departments of Health Research and Policy and Statistics, Genetics, Pathology, Surgery, and Biochemistry and Howard Hughes Medical Institute, Stanford University School of Medicine, Stanford, CA 94305; Departments of Medicine (Section of Oncology), Surgery, and BiochemicalStephanie GeislerDepartments of Genetics and Surgery, The Norwegian Radium Hospital, Montebello, N-0310 Oslo, Norway; Department of Genetics and Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC 27599; Departments of Health Research and Policy and Statistics, Genetics, Pathology, Surgery, and Biochemistry and Howard Hughes Medical Institute, Stanford University School of Medicine, Stanford, CA 94305; Departments of Medicine (Section of Oncology), Surgery, and BiochemicalHilde JohnsenDepartments of Genetics and Surgery, The Norwegian Radium Hospital, Montebello, N-0310 Oslo, Norway; Department of Genetics and Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC 27599; Departments of Health Research and Policy and Statistics, Genetics, Pathology, Surgery, and Biochemistry and Howard Hughes Medical Institute, Stanford University School of Medicine, Stanford, CA 94305; Departments of Medicine (Section of Oncology), Surgery, and BiochemicalTrevor HastieDepartments of Genetics and Surgery, The Norwegian Radium Hospital, Montebello, N-0310 Oslo, Norway; Department of Genetics and Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC 27599; Departments of Health Research and Policy and Statistics, Genetics, Pathology, Surgery, and Biochemistry and Howard Hughes Medical Institute, Stanford University School of Medicine, Stanford, CA 94305; Departments of Medicine (Section of Oncology), Surgery, and BiochemicalMichael B. EisenDepartments of Genetics and Surgery, The Norwegian Radium Hospital, Montebello, N-0310 Oslo, Norway; Department of Genetics and Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC 27599; Departments of Health Research and Policy and Statistics, Genetics, Pathology, Surgery, and Biochemistry and Howard Hughes Medical Institute, Stanford University School of Medicine, Stanford, CA 94305; Departments of Medicine (Section of Oncology), Surgery, and BiochemicalMatt van de RijnDepartments of Genetics and Surgery, The Norwegian Radium Hospital, Montebello, N-0310 Oslo, Norway; Department of Genetics and Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC 27599; Departments of Health Research and Policy and Statistics, Genetics, Pathology, Surgery, and Biochemistry and Howard Hughes Medical Institute, Stanford University School of Medicine, Stanford, CA 94305; Departments of Medicine (Section of Oncology), Surgery, and BiochemicalStefanie S. JeffreyDepartments of Genetics and Surgery, The Norwegian Radium Hospital, Montebello, N-0310 Oslo, Norway; Department of Genetics and Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC 27599; Departments of Health Research and Policy and Statistics, Genetics, Pathology, Surgery, and Biochemistry and Howard Hughes Medical Institute, Stanford University School of Medicine, Stanford, CA 94305; Departments of Medicine (Section of Oncology), Surgery, and BiochemicalThor ThorsenDepartments of Genetics and Surgery, The Norwegian Radium Hospital, Montebello, N-0310 Oslo, Norway; Department of Genetics and Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC 27599; Departments of Health Research and Policy and Statistics, Genetics, Pathology, Surgery, and Biochemistry and Howard Hughes Medical Institute, Stanford University School of Medicine, Stanford, CA 94305; Departments of Medicine (Section of Oncology), Surgery, and BiochemicalH. QuistDepartments of Genetics and Surgery, The Norwegian Radium Hospital, Montebello, N-0310 Oslo, Norway; Department of Genetics and Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC 27599; Departments of Health Research and Policy and Statistics, Genetics, Pathology, Surgery, and Biochemistry and Howard Hughes Medical Institute, Stanford University School of Medicine, Stanford, CA 94305; Departments of Medicine (Section of Oncology), Surgery, and BiochemicalJohn C. MateseDepartments of Genetics and Surgery, The Norwegian Radium Hospital, Montebello, N-0310 Oslo, Norway; Department of Genetics and Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC 27599; Departments of Health Research and Policy and Statistics, Genetics, Pathology, Surgery, and Biochemistry and Howard Hughes Medical Institute, Stanford University School of Medicine, Stanford, CA 94305; Departments of Medicine (Section of Oncology), Surgery, and BiochemicalPatrick O. BrownDepartments of Genetics and Surgery, The Norwegian Radium Hospital, Montebello, N-0310 Oslo, Norway; Department of Genetics and Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC 27599; Departments of Health Research and Policy and Statistics, Genetics, Pathology, Surgery, and Biochemistry and Howard Hughes Medical Institute, Stanford University School of Medicine, Stanford, CA 94305; Departments of Medicine (Section of Oncology), Surgery, and BiochemicalDavid BotsteinDepartments of Genetics and Surgery, The Norwegian Radium Hospital, Montebello, N-0310 Oslo, Norway; Department of Genetics and Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC 27599; Departments of Health Research and Policy and Statistics, Genetics, Pathology, Surgery, and Biochemistry and Howard Hughes Medical Institute, Stanford University School of Medicine, Stanford, CA 94305; Departments of Medicine (Section of Oncology), Surgery, and BiochemicalPer Eystein LønningDepartments of Genetics and Surgery, The Norwegian Radium Hospital, Montebello, N-0310 Oslo, Norway; Department of Genetics and Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC 27599; Departments of Health Research and Policy and Statistics, Genetics, Pathology, Surgery, and Biochemistry and Howard Hughes Medical Institute, Stanford University School of Medicine, Stanford, CA 94305; Departments of Medicine (Section of Oncology), Surgery, and BiochemicalAnne‐Lise Børresen‐DaleDepartments of Genetics and Surgery, The Norwegian Radium Hospital, Montebello, N-0310 Oslo, Norway; Department of Genetics and Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC 27599; Departments of Health Research and Policy and Statistics, Genetics, Pathology, Surgery, and Biochemistry and Howard Hughes Medical Institute, Stanford University School of Medicine, Stanford, CA 94305; Departments of Medicine (Section of Oncology), Surgery, and Biochemical
2001en
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Annotatsiya
The purpose of this study was to classify breast carcinomas based on variations in gene expression patterns derived from cDNA microarrays and to correlate tumor characteristics to clinical outcome. A total of 85 cDNA microarray experiments representing 78 cancers, three fibroadenomas, and four normal breast tissues were analyzed by hierarchical clustering. As reported previously, the cancers could be classified into a basal epithelial-like group, an ERBB2-overexpressing group and a normal breast-like group based on variations in gene expression. A novel finding was that the previously characterized luminal epithelial/estrogen receptor-positive group could be divided into at least two subgroups, each with a distinctive expression profile. These subtypes proved to be reasonably robust by clustering using two different gene sets: first, a set of 456 cDNA clones previously selected to reflect intrinsic properties of the tumors and, second, a gene set that highly correlated with patient outcome. Survival analyses on a subcohort of patients with locally advanced breast cancer uniformly treated in a prospective study showed significantly different outcomes for the patients belonging to the various groups, including a poor prognosis for the basal-like subtype and a significant difference in outcome for the two estrogen receptor-positive groups.
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