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MALAT1: a druggable long non-coding RNA for targeted anti-cancer approaches

Nicola AmodioDepartment of Experimental and Clinical Medicine, Magna Graecia University, Viale Europa, 88100, Catanzaro, Italy. [email protected]Lavinia RaimondiIRCSS Rizzoli Orthopedic Institute, Bologna, ItalyGiada JuliDepartment of Experimental and Clinical Medicine, Magna Graecia University, Viale Europa, 88100, Catanzaro, ItalyMaria Angelica StamatoDepartment of Experimental and Clinical Medicine, Magna Graecia University, Viale Europa, 88100, Catanzaro, ItalyDaniele CaraccioloDepartment of Experimental and Clinical Medicine, Magna Graecia University, Viale Europa, 88100, Catanzaro, ItalyPierosandro TagliaferriDepartment of Experimental and Clinical Medicine, Magna Graecia University, Viale Europa, 88100, Catanzaro, ItalyPierfrancesco TassoneDepartment of Experimental and Clinical Medicine, Magna Graecia University, Viale Europa, 88100, Catanzaro, Italy. [email protected]

2018en

ABI

Annotatsiya

The deeper understanding of non-coding RNAs has recently changed the dogma of molecular biology assuming protein-coding genes as unique functional biological effectors, while non-coding genes as junk material of doubtful significance. In the last decade, an exciting boom of experimental research has brought to light the pivotal biological functions of long non-coding RNAs (lncRNAs), representing more than the half of the whole non-coding transcriptome, along with their dysregulation in many diseases, including cancer.In this review, we summarize the emerging insights on lncRNA expression and functional role in cancer, focusing on the evolutionary conserved and abundantly expressed metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) that currently represents the best characterized lncRNA. Altogether, literature data indicate aberrant expression and dysregulated activity of MALAT1 in human malignancies and envision MALAT1 targeting as a novel treatment strategy against cancer.

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DOI: 10.1186/s13045-018-0606-4

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