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Mesoporous silica nanoparticles in biomedical applications

Zongxi LiCalifornia NanoSystems Institute and Department of Chemistry and Biochemistry, University of California, 607 Charles E. Young Drive East, Los Angeles, California 90095, USAJonathan C. BarnesDepartment of Chemistry, Northwestern University, 2145 Sheridan Road, Evanston, USAAleksandr BosoyDepartment of Chemistry, Northwestern University, 2145 Sheridan Road, Evanston, USAJ. Fraser StoddartDepartment of Chemistry, Northwestern University, 2145 Sheridan Road, Evanston, USAJeffrey I. ZinkCalifornia NanoSystems Institute and Department of Chemistry and Biochemistry, University of California, 607 Charles E. Young Drive East, Los Angeles, USA

2012en

ABI

Annotatsiya

This tutorial review provides an outlook on nanomaterials that are currently being used for theranostic purposes, with a special focus on mesoporous silica nanoparticle (MSNP) based materials. MSNPs with large surface area and pore volume can serve as efficient carriers for various therapeutic agents. The functionalization of MSNPs with molecular, supramolecular or polymer moieties, provides the material with great versatility while performing drug delivery tasks, which makes the delivery process highly controllable. This emerging area at the interface of chemistry and the life sciences offers a broad palette of opportunities for researchers with interests ranging from sol-gel science, the fabrication of nanomaterials, supramolecular chemistry, controllable drug delivery and targeted theranostics in biology and medicine.

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DOI: 10.1039/c1cs15246g

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