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Phage-Encoded Endolysins

Fatma AbdelrahmanCenter for Microbiology and Phage Therapy, Biomedical Sciences, Zewail City of Science and Technology, Giza 12578, EgyptMaheswaran EaswaranOluwasegun I. DaramolaDepartment of Biomedical Laboratory Science, College of Medicine, University of Ibadan, Ibadan 200284, NigeriaSamar RagabCenter for Microbiology and Phage Therapy, Biomedical Sciences, Zewail City of Science and Technology, Giza 12578, EgyptStephanie LynchSchool of Life Sciences, La Trobe University, Melbourne, VIC 3086, AustraliaTolulope J. OduseluDepartment of Biomedical Laboratory Science, College of Medicine, University of Ibadan, Ibadan 200284, NigeriaFazal Mehmood KhanCenter for Biosafety Mega-Science, Key Laboratory of Special Pathogens and Biosafety, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan 430071, ChinaAkomolafe AyobamiDepartment of Biomedical Laboratory Science, College of Medicine, University of Ibadan, Ibadan 200284, NigeriaFazal AdnanAtta ur Rahman School of Applied Biosciences (ASAB), National University of Sciences and Technology (NUST), Islamabad 24090, PakistanEduard TorrentsBacterial Infections: Antimicrobial Therapies Group, Institute for Bioengineering of Catalonia (IBEC), The Barcelona Institute of Science and Technology (BIST), 08028 Barcelona, SpainSwapnil Ganesh SanmukhBacterial Infections: Antimicrobial Therapies Group, Institute for Bioengineering of Catalonia (IBEC), The Barcelona Institute of Science and Technology (BIST), 08028 Barcelona, SpainAyman El‐ShibinyCenter for Microbiology and Phage Therapy, Biomedical Sciences, Zewail City of Science and Technology, Giza 12578, Egypt

2021en

ABI

Annotatsiya

Due to the global emergence of antibiotic resistance, there has been an increase in research surrounding endolysins as an alternative therapeutic. Endolysins are phage-encoded enzymes, utilized by mature phage virions to hydrolyze the cell wall from within. There is significant evidence that proves the ability of endolysins to degrade the peptidoglycan externally without the assistance of phage. Thus, their incorporation in therapeutic strategies has opened new options for therapeutic application against bacterial infections in the human and veterinary sectors, as well as within the agricultural and biotechnology sectors. While endolysins show promising results within the laboratory, it is important to document their resistance, safety, and immunogenicity for in-vivo application. This review aims to provide new insights into the synergy between endolysins and antibiotics, as well as the formulation of endolysins. Thus, it provides crucial information for clinical trials involving endolysins.

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Identifikatorlar

DOI: 10.3390/antibiotics10020124

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