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The commensal microbiome is associated with anti–PD-1 efficacy in metastatic melanoma patients

Vyara MatsonDepartment of Pathology, University of Chicago, Chicago, IL 60637, USAJessica FesslerDepartment of Pathology, University of Chicago, Chicago, IL 60637, USARiyue BaoCenter for Research Informatics, University of Chicago, IL 60637, USATara ChongsuwatDepartment of Medicine, University of Chicago, Chicago, IL 60637, USAYuanyuan ZhaDepartment of Medicine, University of Chicago, Chicago, IL 60637, USAMaria‐Luisa AlegreDepartment of Medicine, University of Chicago, Chicago, IL 60637, USAJason J. LukeDepartment of Medicine, University of Chicago, Chicago, IL 60637, USAThomas F. GajewskiDepartment of Medicine, University of Chicago, Chicago, IL 60637, USA

2018en

ABI

Annotatsiya

Good bacteria help fight cancer Resident gut bacteria can affect patient responses to cancer immunotherapy (see the Perspective by Jobin). Routy et al. show that antibiotic consumption is associated with poor response to immunotherapeutic PD-1 blockade. They profiled samples from patients with lung and kidney cancers and found that nonresponding patients had low levels of the bacterium Akkermansia muciniphila . Oral supplementation of the bacteria to antibiotic-treated mice restored the response to immunotherapy. Matson et al. and Gopalakrishnan et al. studied melanoma patients receiving PD-1 blockade and found a greater abundance of “good” bacteria in the guts of responding patients. Nonresponders had an imbalance in gut flora composition, which correlated with impaired immune cell activity. Thus, maintaining healthy gut flora could help patients combat cancer. Science , this issue p. 91 , p. 104 , p. 97 ; see also p. 32

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Identifikatorlar

DOI: 10.1126/science.aao3290

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