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Transgenic fluorescent zebrafish lines that have revolutionized biomedical research

Chong Pyo ChoeDivision of Applied Life Science, Plant Molecular Biology and Biotechnology Research Center, Gyeongsang National University, Jinju, 52828, Republic of KoreaSeok‐Yong ChoiDepartment of Biomedical Sciences, Chonnam National University Medical School, Hwasun, 58128, Republic of KoreaYun KeeDivision of Biomedical Convergence, College of Biomedical Science, Kangwon National University, Chuncheon, 24341, Republic of Korea. [email protected]Jong Min KimDepartment of Biological Sciences, Sookmyung Women's University, Seoul, 04310, Republic of KoreaSeok-Hyung KimDepartment of Marine Life Sciences and Fish Vaccine Research Center, Jeju National University, Jeju, 63243, Republic of KoreaYoonsung LeeCenter for Genomic Integrity, Institute for Basic Science (IBS), Ulsan, 44919, Republic of KoreaHae‐Chul ParkDepartment of Biomedical Sciences, College of Medicine, Korea University, Ansan, 15355, Republic of KoreaHyunju RoDepartment of Biological Sciences, College of Bioscience and Biotechnology, Chungnam National University, Daejeon, 34134, Republic of Korea

2021en

ABI

Annotatsiya

Since its debut in the biomedical research fields in 1981, zebrafish have been used as a vertebrate model organism in more than 40,000 biomedical research studies. Especially useful are zebrafish lines expressing fluorescent proteins in a molecule, intracellular organelle, cell or tissue specific manner because they allow the visualization and tracking of molecules, intracellular organelles, cells or tissues of interest in real time and in vivo. In this review, we summarize representative transgenic fluorescent zebrafish lines that have revolutionized biomedical research on signal transduction, the craniofacial skeletal system, the hematopoietic system, the nervous system, the urogenital system, the digestive system and intracellular organelles.

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DOI: 10.1186/s42826-021-00103-2

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