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White light-excited organic room-temperature phosphorescence for improved in vivo bioimaging

Lutong ZhangSchool of Chemistry and Materials Engineering, Wenzhou University, Wenzhou, P. R. ChinaJi-Sen LiFrontiers Science Center for New Organic Matter, State Key Laboratory of Medicinal Chemical Biology, MOE Key Laboratory of Bioactive Materials, and College of Life Sciences, Nankai University, Tianjin, P.R. ChinaYifan ZhangFrontiers Science Center for New Organic Matter, State Key Laboratory of Medicinal Chemical Biology, MOE Key Laboratory of Bioactive Materials, and College of Life Sciences, Nankai University, Tianjin, P.R. ChinaWenbo DaiKey Lab of Biohealth Materials and Chemistry of Wenzhou, Wenzhou, P. R. China. [email protected]Yufan ZhangFrontiers Science Center for New Organic Matter, State Key Laboratory of Medicinal Chemical Biology, MOE Key Laboratory of Bioactive Materials, and College of Life Sciences, Nankai University, Tianjin, P.R. ChinaXue Dong GaoSchool of Chemistry and Materials Engineering, Wenzhou University, Wenzhou, P. R. ChinaMiaochang LiuSchool of Chemistry and Materials Engineering, Wenzhou University, Wenzhou, P. R. ChinaHuayue WuSchool of Chemistry and Materials Engineering, Wenzhou University, Wenzhou, P. R. ChinaXiaobo HuangSchool of Chemistry and Materials Engineering, Wenzhou University, Wenzhou, P. R. ChinaYunxiang LeiKey Lab of Biohealth Materials and Chemistry of Wenzhou, Wenzhou, P. R. China. [email protected]Dan DingFrontiers Science Center for New Organic Matter, State Key Laboratory of Medicinal Chemical Biology, MOE Key Laboratory of Bioactive Materials, and College of Life Sciences, Nankai University, Tianjin, P.R. China. [email protected]

2025en

ABI

Annotatsiya

Organic phosphorescence materials offer significant advantages for bioimaging applications. However, most of these materials are excited exclusively by ultraviolet (UV) light, which poses risks to living organisms. Herein, six donor–acceptor-type compounds incorporating triazine groups are designed as guests within doped systems. White-light excitable phosphorescent guests enable doped materials to show efficient afterglow under white-light excitation. By leveraging the ability of white-light to penetrate biological tissues, a bioimaging mode in which the materials are first concentrated within the organism and then excited was developed, yielding superior imaging effects compared with the traditional method in which materials are first excited and then concentrated. Furthermore, these materials are applied in imaging diagnosis of atherosclerosis plaques (male Apoe−/− mice) and intestinal diseases (female BALB/c-nude mice), as well as in navigation for in situ liver tumor surgery (female BALB/c-nude mice), achieving excellent imaging outcomes. This work addresses the limitations of phosphorescent materials that rely on UV-light, significantly enhancing their potential for practical applications in clinical imaging. Organic phosphorescence materials offer advantages for bioimaging applications, but most of them are excited exclusively by ultraviolet light, which poses risks to living organisms. Here, the author report doped materials with white-light activated phosphorescence activity, and a bioimaging mode in which these phosphorescent materials are first concentrated within the organism and then excited.

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Identifikatorlar

DOI: 10.1038/s41467-025-59367-0

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