Commensal Gut Bacteria Convert the Immunosuppressant Tacrolimus to Less Potent Metabolites
Yukuang GuoDepartments of Medicinal Chemistry and Pharmacognosy (Y.G., C.M.C., J.O., H.L.), Pharmacy Practice (K.-J.W., H.J.), Biopharmaceutical Sciences (X.Y., H.J.), and Center for Biomolecular Sciences (Y.G., J.O., H.L., H.J.), University of Illinois at Chicago, Chicago, Illinois; and Division of Nephrology and Hypertension, Department of Medicine, Weill Cornell Medicine, New York, New York (J.R.L.)Camila Manoel CrnkovicDepartments of Medicinal Chemistry and Pharmacognosy (Y.G., C.M.C., J.O., H.L.), Pharmacy Practice (K.-J.W., H.J.), Biopharmaceutical Sciences (X.Y., H.J.), and Center for Biomolecular Sciences (Y.G., J.O., H.L., H.J.), University of Illinois at Chicago, Chicago, Illinois; and Division of Nephrology and Hypertension, Department of Medicine, Weill Cornell Medicine, New York, New York (J.R.L.)Kyoung‐Jae WonDepartments of Medicinal Chemistry and Pharmacognosy (Y.G., C.M.C., J.O., H.L.), Pharmacy Practice (K.-J.W., H.J.), Biopharmaceutical Sciences (X.Y., H.J.), and Center for Biomolecular Sciences (Y.G., J.O., H.L., H.J.), University of Illinois at Chicago, Chicago, Illinois; and Division of Nephrology and Hypertension, Department of Medicine, Weill Cornell Medicine, New York, New York (J.R.L.)Xiaotong YangDepartments of Medicinal Chemistry and Pharmacognosy (Y.G., C.M.C., J.O., H.L.), Pharmacy Practice (K.-J.W., H.J.), Biopharmaceutical Sciences (X.Y., H.J.), and Center for Biomolecular Sciences (Y.G., J.O., H.L., H.J.), University of Illinois at Chicago, Chicago, Illinois; and Division of Nephrology and Hypertension, Department of Medicine, Weill Cornell Medicine, New York, New York (J.R.L.)John R. LeeDepartments of Medicinal Chemistry and Pharmacognosy (Y.G., C.M.C., J.O., H.L.), Pharmacy Practice (K.-J.W., H.J.), Biopharmaceutical Sciences (X.Y., H.J.), and Center for Biomolecular Sciences (Y.G., J.O., H.L., H.J.), University of Illinois at Chicago, Chicago, Illinois; and Division of Nephrology and Hypertension, Department of Medicine, Weill Cornell Medicine, New York, New York (J.R.L.)Jimmy OrjalaDepartments of Medicinal Chemistry and Pharmacognosy (Y.G., C.M.C., J.O., H.L.), Pharmacy Practice (K.-J.W., H.J.), Biopharmaceutical Sciences (X.Y., H.J.), and Center for Biomolecular Sciences (Y.G., J.O., H.L., H.J.), University of Illinois at Chicago, Chicago, Illinois; and Division of Nephrology and Hypertension, Department of Medicine, Weill Cornell Medicine, New York, New York (J.R.L.) [email protected] [email protected] [email protected]Hyunwoo LeeDepartments of Medicinal Chemistry and Pharmacognosy (Y.G., C.M.C., J.O., H.L.), Pharmacy Practice (K.-J.W., H.J.), Biopharmaceutical Sciences (X.Y., H.J.), and Center for Biomolecular Sciences (Y.G., J.O., H.L., H.J.), University of Illinois at Chicago, Chicago, Illinois; and Division of Nephrology and Hypertension, Department of Medicine, Weill Cornell Medicine, New York, New York (J.R.L.) [email protected] [email protected] [email protected]Hyunyoung JeongDepartments of Medicinal Chemistry and Pharmacognosy (Y.G., C.M.C., J.O., H.L.), Pharmacy Practice (K.-J.W., H.J.), Biopharmaceutical Sciences (X.Y., H.J.), and Center for Biomolecular Sciences (Y.G., J.O., H.L., H.J.), University of Illinois at Chicago, Chicago, Illinois; and Division of Nephrology and Hypertension, Department of Medicine, Weill Cornell Medicine, New York, New York (J.R.L.) [email protected] [email protected] [email protected]
2018en
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