Research advances on short-chain fatty acids in gastrointestinal acute graft- <i>versus</i> -host disease
Xinping SongShenzhen Children’s Hospital, China Medical University, Shenzhen, Guangdong 518026, ChinaJing LaoShenzhen Children’s Hospital, China Medical University, Shenzhen, Guangdong 518026, ChinaLulu WangDepartment of Hematology and Oncology, Shenzhen Children’s Hospital, 7019 Yitian Road, Futian District, Shenzhen, Guangdong 518026, ChinaSixi LiuDepartment of Hematology and Oncology, Shenzhen Children’s Hospital, 7019 Yitian Road, Futian District, Shenzhen, Guangdong 518026, China
2024en
ABI
Annotatsiya
-host disease (GI-aGVHD) is a severe early complication following allogeneic hematopoietic stem cell transplantation (allo-HSCT). It has been shown that the intestinal microbiota plays a critical role in this process. As metabolites of the intestinal microbiota, short-chain fatty acids (SCFAs) are vital for maintaining the host-microbiota symbiotic equilibrium. This article provides an overview of the protective effect of SCFAs in the gastrointestinal tract, emphasizes their association with GI-aGVHD, and explores relevant research progress in prevention and treatment research.
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