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A practical introduction to holo-omics

Iñaki OdriozolaCenter for Evolutionary Hologenomics, Globe Institute, University of Copenhagen, Copenhagen, DenmarkJacob Agerbo RasmussenCenter for Evolutionary Hologenomics, Globe Institute, University of Copenhagen, Copenhagen, DenmarkM. Thomas P. GilbertCenter for Evolutionary Hologenomics, Globe Institute, University of Copenhagen, Copenhagen, Denmark; University Museum, NTNU, Trondheim, NorwayMorten T. LimborgCenter for Evolutionary Hologenomics, Globe Institute, University of Copenhagen, Copenhagen, DenmarkAntton AlberdiCenter for Evolutionary Hologenomics, Globe Institute, University of Copenhagen, Copenhagen, Denmark. Electronic address: [email protected]

2024en

ABI

Annotatsiya

Holo-omics refers to the joint study of non-targeted molecular data layers from host-microbiota systems or holobionts, which is increasingly employed to disentangle the complex interactions between the elements that compose them. We navigate through the generation, analysis, and integration of omics data, focusing on the commonalities and main differences to generate and analyze the various types of omics, with a special focus on optimizing data generation and integration. We advocate for careful generation and distillation of data, followed by independent exploration and analyses of the single omic layers to obtain a better understanding of the study system, before the integration of multiple omic layers in a final model is attempted. We highlight critical decision points to achieve this aim and flag the main challenges to address complex biological questions regarding the integrative study of host-microbiota relationships.

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DOI: 10.1016/j.crmeth.2024.100820

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