Novel hybrids of thiazolidinedione-1,3,4-oxadiazole derivatives: synthesis, molecular docking, MD simulations, ADMET study,<i>in vitro</i>, and<i>in vivo</i>anti-diabetic assessment
Mahendra Gowdru SrinivasaDepartment of Pharmaceutical Chemistry, NGSM Institute of Pharmaceutical Sciences (NGSMIPS), Nitte (Deemed to Be University), Mangalore-575018, Karnataka, IndiaJagdish Gopal PaithankarDivision of Environmental Health and Toxicology, Nitte University Centre for Science Education and Research (NUCSER), Nitte (Deemed to Be University), Mangalore-575018, Karnataka, IndiaSumit BirangalDepartment of Pharmaceutical Chemistry, Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education (MAHE), Manipal-5761042, Karnataka, IndiaAravinda PaiDepartment of Pharmaceutical Chemistry, Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education (MAHE), Manipal-5761042, Karnataka, IndiaVasudev Baburaya PaiDepartment of Pharmacognosy, Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education (MAHE), Manipal-5761042, Karnataka, IndiaShridhar N. DeshpandeDepartment of Pharmaceutical Chemistry, NGSM Institute of Pharmaceutical Sciences (NGSMIPS), Nitte (Deemed to Be University), Mangalore-575018, Karnataka, IndiaB. C. RevanasiddappaDepartment of Pharmaceutical Chemistry, NGSM Institute of Pharmaceutical Sciences (NGSMIPS), Nitte (Deemed to Be University), Mangalore-575018, Karnataka, India
2023en
ABI
Annotatsiya
studies have shown that compounds 5a, 5b, and 5j lower glucose levels in Drosophila. These compounds could be further developed in the future to produce a new class of antidiabetic agents.
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