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Bovine Coronavirus Immune Milk Against COVID-19

Antonio ArenasDepartment of Animal Health, University of Cordoba, Córdoba, SpainCarmen BorgeDepartment of Animal Health, University of Cordoba, Córdoba, SpainAlfonso CarboneroDepartment of Animal Health, University of Cordoba, Córdoba, SpainIgnacio García‐BocanegraDepartment of Animal Health, University of Cordoba, Córdoba, SpainDavid Cano‐TerrizaDepartment of Animal Health, University of Cordoba, Córdoba, SpainJavier Caballero‐GómezDepartment of Animal Health, University of Cordoba, Córdoba, SpainAntonio Arenas‐MontesDepartment of Animal Health, University of Cordoba, Córdoba, Spain

2021en

ABI

Annotatsiya

After a year of evolution of the SARS-CoV-2 epidemic, there is still no specific effective treatment for the disease. Although the majority of infected people experience mild disease, some patients develop a serious disease, especially when other pathologies concur. For this reason, it would be very convenient to find pharmacological and immunological mechanisms that help control SARS-CoV-2 infection. Since the COVID-19 and BCoV viruses are very close phylogenetically, different studies demonstrate the existence of cross-immunity as they retain shared epitopes in their structure. As a possible control measure against COVID-19, we propose the use of cow's milk immune to BCoV. Thus, the antigenic recognition of some highly conserved structures of viral proteins, particularly M and S2, by anti-BCoV antibodies present in milk would cause a total or partial inactivation of SARS-COV-2 (acting as a particular vaccine) and be addressed more easily by GALT's highly specialized antigen-presenting cells, thus helping the specific immune response.

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Identifikatorlar

DOI: 10.3389/fimmu.2021.637152

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