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The effect of humic substances on gut microbiota and immune response of broilers

Dagmar MudroňováDepartment of Microbiology and Immunology, University of Veterinary Medicine and PharmacyViera KaraffováDepartment of Pathological Anatomy and Pathological Physiology, University of Veterinary Medicine and PharmacyT. PešulováDepartment of Microbiology and Immunology, University of Veterinary Medicine and PharmacyJana KoščováDepartment of Microbiology and Immunology, University of Veterinary Medicine and PharmacyIvana Cingeľová MaruščákováDepartment of Microbiology and Immunology, University of Veterinary Medicine and PharmacyMartin BartkovskýDepartment of Food Hygiene and Technology, University of Veterinary Medicine and PharmacyDana MarcinčákováDepartment of Food Hygiene and Technology, University of Veterinary Medicine and PharmacyZuzana ŠevčíkováDepartment of Pathological Anatomy and Pathological Physiology, University of Veterinary Medicine and PharmacySlavomír MarcinčákDepartment of Food Hygiene and Technology, University of Veterinary Medicine and Pharmacy

2020en

ABI

Annotatsiya

The work focused on the study of the immunomodulatory and gut-protecting effect of humic substances (HS) in broilers. The diet of experimental chicks was enriched with 0.8% of HS. We noted that HS had a stimulatory effect on the phagocytic activity and the engulfing capacity of phagocytes, however, the level of oxidative burst of phagocytes was not affected. We observed a significant increase of CD4+: CD8+ lymphocyte ratio, an indicator of immune stimulation. HS did not influence the IgA gene expression. In contrast, we observed a significant increase in the expression of MUC-2 (intestinal mucin 2) gene, and a decrease in the expression of IGF-2 (insulin-like growth factor 2) and also AvBD2 (avian beta defensin 2) genes. A decreased Enterobacteriaceae counts in the gut of experimental animals showed a positive effect on intestinal microbiota. We confirmed a gut-protecting and an immunostimulatory effect of HS in broiler chickens.

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Identifikatorlar

DOI: 10.1080/09540105.2019.1707780

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