One‐step synthesis of 2‐amino‐5‐(4,5‐diphenylpyrimidin‐2‐ylamino)pentanoic acid from isoflavones and arginine
Zun‐Ting ZhangKey Laboratory of the Ministry of Education for Medicinal Resources and Natural Pharmaceutical Chemistry, National Engineering Laboratory for Resource Development of Endangered Crude Drugs in Northwest of China, and School of Chemistry and Materials Science, Shaanxi Normal University, Xi'an 710062, People's Republic of ChinaWen‐Yong HanKey Laboratory of the Ministry of Education for Medicinal Resources and Natural Pharmaceutical Chemistry, National Engineering Laboratory for Resource Development of Endangered Crude Drugs in Northwest of China, and School of Chemistry and Materials Science, Shaanxi Normal University, Xi'an 710062, People's Republic of ChinaLi QiuKey Laboratory of the Ministry of Education for Medicinal Resources and Natural Pharmaceutical Chemistry, National Engineering Laboratory for Resource Development of Endangered Crude Drugs in Northwest of China, and School of Chemistry and Materials Science, Shaanxi Normal University, Xi'an 710062, People's Republic of China
2010en
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Abstract magnified image A simple and straightforward methodology toward the synthesis of novel 2‐amino‐5‐(4,5‐diphenylpyrimidin‐2‐ylamino)pentanoic acid has been developed by one‐step reaction of isoflavones with arginine. A series of 14 new compounds was reported. All of them were characterized by FTIR, NMR, and elemental analysis. A variety of substrates can participate in the process with good yields and high purities making this methodology suitable for library synthesis in drug discovery. J. Heterocyclic Chem., (2010).
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