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In vivo degradability and biocompatibility of a rheo-formed Mg–Zn–Sr alloy for ureteral implantation

Di TieEngineering Research Center of Continuous Extrusion, Ministry of Education, Dalian Jiaotong University, Dalian 116028, ChinaRenguo GuanEngineering Research Center of Continuous Extrusion, Ministry of Education, Dalian Jiaotong University, Dalian 116028, ChinaHuinan LiuDepartment of Bioengineering, University of California, Riverside, CA 92521, USAMinfang ChenSchool of Materials Science and Engineering, Tianjin University of Technology, Tianjin 300384, ChinaSviatlana A. UlasevichInfochemistry Scientific Center, ITMO University, St. Petersburg 192007, RussiaEkaterina V. SkorbInfochemistry Scientific Center, ITMO University, St. Petersburg 192007, RussiaPatricia Holt-TorresDepartment of Bioengineering, University of California, Riverside, CA 92521, USAXiaopeng LuSchool of Materials Science and Engineering, Northeastern University, Shenyang 110819, ChinaNorbert HortMagnesium Innovation Center – MAGIC, Helmholtz Zentrum Geesthacht, Geesthacht D-21502, Germany

2021en

ABI

Annotatsiya

The introduction of biodegradable implant materials has significantly improved the postoperative subjective feelings of patients within the past few decades, among which magnesium alloy is widely considered a favorable choice as its appropriate biodegradability and evident antibacterial activity. Here, we reveal a semisolid rheo-formed Mg–Zn–Sr alloy ureteral implant that displayed suitable degradability and biocompatibility in a pig model. Refined non-dendritic microstructure was observed in the rheo-formed alloy, which led to ca. 47% increase in ultimate tensile strength (from 195.0 MPa to 288.1 MPa) and more homogeneous degradation process compared with the untreated alloy. No post-interventional inflammation or pathological changes of the test animals were observed during the implantation period, and the corrosion rate (0.22 ± 0.04 mm·y−1) perfectly fitted the clinical ureteral stent indwelling time. The urine bacteria numbers decreased from 88 ± 13 CFU·mL−1 at 7 weeks post operation to 59 ± 8 CFU·mL−1 at 14 weeks post operation, which confirmed the evident antibacterial activity of the alloy. Our study demonstrates that the Mg–Zn–Sr alloy is clinically safe for urinary system, enabling its efficacious use as ureteral implant materials.

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Identifikatorlar

DOI: 10.1016/j.jma.2020.11.005

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