Synthesis, Characterization and Anti‐inflammatory Activity of 5‐{[((5‐Substituted‐aryl)‐1,3,4‐thiadiazol‐2‐yl)thio]‐<i>n</i>‐alkyl}‐1,3,4‐oxadiazole‐2‐thiol
Pramodkumar J. ShiroteDepartment of Pharmaceutical Chemistry, Bharati Vidyapeeth College of Pharmacy, Near Chitranagari, Morewadi, Kolhapur, 416013, IndiaManish S. BhatiaDepartment of Pharmaceutical Chemistry, Bharati Vidyapeeth College of Pharmacy, Near Chitranagari, Morewadi, Kolhapur, 416013, India
2010en
ABI
Annotatsiya
Abstract A series of potent and less toxic, 5‐{[((5‐substituted aryl)‐1,3,4‐thiadiazol‐2‐yl) thio]‐ n ‐alkyl}‐1,3,4‐oxadiazole‐2‐thiol was synthesized. Each compound was evaluated for anti‐inflammatory activity by carrageenan‐induced rat paw oedema method. Compounds PS1 , PS4 , PS9 , and PS12 showed comparatively potent anti‐inflammatory activity as compared to control as well as other test compounds. These potent compounds were also tested for acute ulcerogenic activity. Results of both studies were found statistically significant.
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