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Phytochemical investigation and antimicrobial activity of an endophytic fungus Phoma sp.

Hidayat HussainDepartment of Chemistry, University of Paderborn, Warburger Strasse 100, 33098 Paderborn, GermanyMarkus JohnDepartment of Chemistry, University of Paderborn, Warburger Strasse 100, 33098 Paderborn, GermanyAhmed Al‐HarrasiUoN Chair of Oman’s Medicinal Plants and Marine Natural Products, University of Nizwa, PO Box 33, Postal Code 616, Birkat Al Mauz, Nizwa, OmanAfzal ShahDepartment of Chemistry, Quaid-i-Azam University, 45320 Islamabad, PakistanZahid HassanUoN Chair of Oman’s Medicinal Plants and Marine Natural Products, University of Nizwa, PO Box 33, Postal Code 616, Birkat Al Mauz, Nizwa, OmanGhulam AbbasUoN Chair of Oman’s Medicinal Plants and Marine Natural Products, University of Nizwa, PO Box 33, Postal Code 616, Birkat Al Mauz, Nizwa, OmanUsman Ali RanaDeanship of Scientific Research, College of Engineering, King Saud University, Riyadh 11421, Saudi ArabiaIvan R. GreenDepartment of Chemistry and Polymer Science, University of Stellenbosch, P/Bag X1, Matieland 7602, South AfricaBarbara SchulzInstitute of Microbiology, University of Braunschweig, Spielmannstraße 7, 38106 Braunschweig, GermanyKarsten KrohnDepartment of Chemistry, University of Paderborn, Warburger Strasse 100, 33098 Paderborn, Germany

2014en

ABI

Annotatsiya

Phytochemical investigation of the endophytic fungi Phoma sp. resulted in the isolation of sclerodin (1), 8,9-dihydro-3,5,7-trihydroxy-1,8,8,9-tetramethyl-5-(2-oxopropyl)-4H-phenaleno[1,2-b]furan-4,6(5H)-dione (2), atrovenetinone (3), and sclerodione (4). Preliminary studies showed that sclerodin (1) displayed moderate antialgal activity while 8,9-dihydro-3,5,7-trihydroxy-1,8,8,9-tetramethyl-5-(2-oxopropyl)-4H-phenaleno[1,2-b]furan-4,6(5H)-dione (2), atrovenetinone (3), and sclerodione (4) displayed moderate antifungal activity. Furthermore 8,9-dihydro-3,5,7-trihydroxy-1,8,8,9-tetramethyl-5-(2-oxopropyl)-4H-phenaleno[1,2-b]furan-4,6(5H)-dione (2) and atrovenetinone (3) showed moderate antibacterial activity against Bacillus megaterium and additionally atrovenetinone (3) showed good antibacterial activity towards Eurotium repens. Furthermore atrovenetinone (3) and sclerodione (4) displayed very strong antifungal activity towards Ustilago violacea.

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DOI: 10.1016/j.jksus.2014.08.001

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