Molecular and pharmacogenetic mechanisms of severe asthma
Е. С. КуликовSiberian State Medical University, Tomsk, Russian FederationЛ. М. ОгородоваMaxim B. FreidinResearch Institute of Medical Genetics, Tomsk, Russian FederationИ. А. ДеевSiberian State Medical University, Tomsk, Russian FederationП. А. СеливановаSiberian State Medical University, Tomsk, Russian FederationС. В. ФедосенкоSiberian State Medical University, Tomsk, Russian FederationН. А. КирилловаSiberian State Medical University, Tomsk, Russian Federation
2013en
ABI
Annotatsiya
This review summarizes the results of studies to identify the dominant mechanisms of development and persistence of inflammation in severe asthma and results of pharmacogenetic studies of determination response to drugs. These mechanisms could potentially be used for diagnostic purposes and become the new targets of asthma therapy. Pharmacogenetic information will enable the use of a personalized approach to the asthma management which will adjust the therapy technology and increase the possibility of achieving disease control.
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