Effect of the walnut polyphenol fraction on oxidative stress in type 2 diabetes mice
Toshiyuki FukudaPOLA Laboratories, POLA Chemical Industries, Inc., 560 Kashio-cho, Totsuka-ku, Yokohama 244-0812, Japan. [email protected]Hideyuki ItoFaculty of Pharmaceutical Sciences, Okayama University, Tsushima, Okayama 700–8530, JapanTakashi YoshidaFaculty of Pharmaceutical Sciences, Okayama University, Tsushima, Okayama 700–8530, Japan
2004en
ABI
Annotatsiya
We examined the in vivo antioxidative effect of a polyphenol-rich walnut extract on oxidative stress in mice with type 2 diabetes. C57BL/KsJ-db/db mice were used as an accelerated oxidative animal model. The oral administration of the walnut polyphenol fraction at 200 mg/kg body weight for 4 weeks caused a significant decrease in the level of urinary 8-hydroxy-2'-deoxyguanosin, which is an in vivo marker of oxidative stress. These results imply that walnut polyphenols have both in vitro and in vivo antioxidant effects.
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