LABEL AND OFF-LABEL APPLICATIONS OF PROTHROMBIN COMPLEX CONCENTRATES. NEW PERSPECTIVES OF OLD DRUGS

The prothrombin complex concentrates (PCCs), containing therapeutic doses of vitamin K-dependent coagulation factors, were licensed for reversal of vitamin K antagonist therapy. However, recently clinicians sought to use PCCs for any number of off-label indications. The goal of this review is to explore practical issues regarding PCCs. Specifically, aims are to examine the role of PCCs in vitamin K antagonist reversal, review its potential use in the treatment of hemorrhage due to direct oral anticoagulants, and explore potential uses in liver disease, trauma-associated bleeding, etc. Safety and other practical considerations of PCCs will also be discussed.

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