In Vitro and In Vivo Activities of Tea Catechins against <i>Helicobacter pylori</i>
Katsuhiro Mabe<!--label omitted: 1-->Second Department of Internal Medicine, Yamagata University School of Medicine, 2-2-2 Iida-Nishi, Yamagata City, Yamagata 990-9585,1Masami Yamada<!--label omitted: 2-->Gastrointestinal Division, Hamamatsu Medical Center, Hamamatsu City, Shizuoka 432-8002,2 andItaro Oguni<!--label omitted: 3-->Department of Food and Nutritional Sciences, University of Shizuoka Hamamatsu College, 3-2-3 Nunohashi, Hamamatsu City, Shizuoka 432-8012,3 JapanTsuneo Takahashi<!--label omitted: 1-->Second Department of Internal Medicine, Yamagata University School of Medicine, 2-2-2 Iida-Nishi, Yamagata City, Yamagata 990-9585,1
1999en
ABI
Annotatsiya
The catechin epigallocatechin gallate showed the strongest activity of the six tea catechins tested against Helicobacter pylori (MIC for 50% of the strains tested, 8 microg/ml). It had bactericidal activity at pH 7 but not at pH </=5.0. In infected Mongolian gerbils, H. pylori was eradicated in 10 to 36% of the catechin-treated animals, with significant decreases in mucosal hemorrhage and erosion. Tea catechins, therefore, may have therapeutic effects on H. pylori infection.
Hali tarjima qilinmagan
Identifikatorlar
Iqtiboslar va manbalar
2 ta iqtibos0 ta foydalanilgan manba