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Structure-Functional Activity Relationship of β-Glucans From the Perspective of Immunomodulation: A Mini-Review

Biao HanLaboratory of Aquaculture & Artemia Reference Center, Faculty of Bioscience Engineering, Ghent University, Gent, BelgiumKartik BaruahDepartment of Animal Nutrition and Management, Faculty of Veterinary Medicine and Animal Sciences, Swedish University of Agricultural Sciences, Uppsala, SwedenEric CoxLaboratory of Immunology, Faculty of Veterinary Medicine, Ghent University, Merelbeke, BelgiumDaisy VanrompayLaboratory of Immunology and Animal Biotechnology, Faculty of Bioscience Engineering, Ghent University, Gent, BelgiumPeter BossierLaboratory of Aquaculture & Artemia Reference Center, Faculty of Bioscience Engineering, Ghent University, Gent, Belgium

2020en

ABI

Annotatsiya

β-Glucans are a heterogeneous group of glucose polymers with a common structure comprising a main chain of β-(1,3) and/or β-(1,4)-glucopyranosyl units, along with side chains with various branches and lengths. β-Glucans initiate immune responses via immune cells, which become activated by the binding of the polymer to specific receptors. However, β-glucans from different sources also differ in their structure, conformation, physical properties, binding affinity to receptors, and thus biological functions. The mechanisms behind this are not fully understood. This mini-review provides a comprehensive and up-to-date commentary on the relationship between β-glucans' structure and function in relation to their use for immunomodulation.

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DOI: 10.3389/fimmu.2020.00658

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