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Sequence Analyses of G-Protein-Coupled Receptors: Similarities to Rhodopsin

Tara MirzadeganRoche Bioscience, Inflammatory Disease Unit, Palo Alto, California 94304, Departments of Ophthalmology, Pharmacology, and Chemistry, University of Washington, Seattle, Washington 98195, International Institute of Molecular and Cell Biology, and Faculty of Chemistry, Warsaw University, Warsaw 02093, PolandGil BenköRoche Bioscience, Inflammatory Disease Unit, Palo Alto, California 94304, Departments of Ophthalmology, Pharmacology, and Chemistry, University of Washington, Seattle, Washington 98195, International Institute of Molecular and Cell Biology, and Faculty of Chemistry, Warsaw University, Warsaw 02093, PolandSławomir FilipekRoche Bioscience, Inflammatory Disease Unit, Palo Alto, California 94304, Departments of Ophthalmology, Pharmacology, and Chemistry, University of Washington, Seattle, Washington 98195, International Institute of Molecular and Cell Biology, and Faculty of Chemistry, Warsaw University, Warsaw 02093, PolandKrzysztof PalczewskiRoche Bioscience, Inflammatory Disease Unit, Palo Alto, California 94304, Departments of Ophthalmology, Pharmacology, and Chemistry, University of Washington, Seattle, Washington 98195, International Institute of Molecular and Cell Biology, and Faculty of Chemistry, Warsaw University, Warsaw 02093, Poland

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G-protein-coupled receptors (GPCRs)() constitute a large superfamily of receptor proteins responsible for signal transduction (see http://www.gpcr.org/7tm). Throughout all higher organisms, these receptors mediate recognition of environmental stimuli like light, odor, and taste, but also hormonal and other types of communications across plasma membranes (1). They are also important targets for pharmacological intervention via activating or blocking their action (2). Three families of GPCRs were identified, with family A being by far the largest (reviewed in refs 3-5). Its members are more closely related to each other within a few functional domains than those of the other families. In addition, numerous diseases have been linked to specific mutations within the genes encoding GPCRs, also making these receptors targets for specific therapeutic interventions including gene transfer (6-9).

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DOI: 10.1021/bi027224+

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