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Iron deficiency or anemia of inflammation?

Manfred NairzDepartment of Internal Medicine VI, Infectious Diseases, Immunology, Rheumatology, Pneumology, Medical University of Innsbruck, Anichstraße 35, 6020, Innsbruck, Austria. [email protected]Igor TheurlDepartment of Internal Medicine VI, Infectious Diseases, Immunology, Rheumatology, Pneumology, Medical University of Innsbruck, Anichstraße 35, 6020, Innsbruck, AustriaDominik Wolf‎Medical Clinic III, Department of Oncology, Hematology and Rheumatology, University Clinic Bonn (UKB), Bonn, GermanyGünter WeißDepartment of Internal Medicine VI, Infectious Diseases, Immunology, Rheumatology, Pneumology, Medical University of Innsbruck, Anichstraße 35, 6020, Innsbruck, Austria. [email protected]

2016de

ABI

Annotatsiya

Iron deficiency and immune activation are the two most frequent causes of anemia, both of which are based on disturbances of iron homeostasis. Iron deficiency anemia results from a reduction of the body's iron content due to blood loss, inadequate dietary iron intake, its malabsorption, or increased iron demand. Immune activation drives a diversion of iron fluxes from the erythropoietic bone marrow, where hemoglobinization takes place, to storage sites, particularly the mononuclear phagocytes system in liver and spleen. This results in iron-limited erythropoiesis and anemia. This review summarizes current diagnostic and pathophysiological concepts of iron deficiency anemia and anemia of inflammation, as well as combined conditions, and provides a brief outlook on novel therapeutic options.

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DOI: 10.1007/s10354-016-0505-7

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