One‐Pot TiO<sub>2</sub>‐Catalyzed Synthesis of Nucleic Bases and Acyclonucleosides from Formamide: Implications for the Origin of Life
Raffaele SaladinoINFM, Dipartimento A.B.A.C. Università della Tuscia, Via San Camillo De Lellis 01100 Viterbo, Italy. [email protected]Umberto CiambecchiniINFM, Dipartimento A.B.A.C. Università della Tuscia, Via San Camillo De Lellis 01100 Viterbo, Italy,Claudia CrestiniDipartimento di Scienze e Tecnologie Chimiche Università “Tor Vergata”, 00133 Rome, ItalyGiovanna CostanzoRodolfo NegriDipartimento di Biologia Cellulare e dello Sviluppo Università“La Sapienza”, 00185 Rome, ItalyErnesto Di MauroDipartimento di Genetica e Biologia Molecolare Università "La Sapienza" P.le Aldo Moro 5 00185 Roma, Italy,
2003en
ABI
Annotatsiya
A novel one-pot TiO2-catalyzed synthesis of nucleobases and acyclonucleosides from formamide is reported. Since formamide can be formed under prebiotic conditions, these reactions have implications for the origin of life. While a number of purine derivatives have been found as products of non-TiO2-catalyzed reactions, important compounds that would not otherwise occur (namely, thymine, 5-hydroxymethyluracil, and acyclonucleosides) are formed in acceptable yields by TiO2-catalyzed reactions. Moreover, TiO2 selectively affects the rates of degradation of nucleobases, as single units and when embedded in polynucleotides.
Hali tarjima qilinmagan
Identifikatorlar
Iqtiboslar va manbalar
2 ta iqtibos0 ta foydalanilgan manba