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Formamide Chemistry and the Origin of Informational Polymers

Raffaele SaladinoDipartimento A. B. A. C., Università della Tuscia, Via San Camillo De Lellis, I-01100 ViterboClaudia CrestiniDipartimento di Scienze e Tecnologie Chimiche, Università ‘Tor Vergata', I-00133 RomeFabiana CicirielloDipartimento di Genetica e Biologia Molecolare, University ‘La Sapienza', P.le Aldo Moro, 5, I-00185 RomeGiovanna CostanzoIstituto di Biologia e Patologia Molecolari, CNR, P.le Aldo Moro, 5, I-00185 RomeErnesto Di MauroFondazione ‘Istituto Pasteur-Fondazione Cenci-Bolognetti', c/o Dipartimento di Genetica e Biologia Molecolare, Università ‘La Sapienza', P.le Aldo Moro, 5, I-00185 Rome, (phone: +39 06 49912880; fax: +39 06 49912500)

2007en

ABI

Annotatsiya

Formamide (HCONH2) provides a chemical frame potentially affording all the monomeric components necessary for the formation of nucleic polymers. In the presence of the appropriate catalysts, and by moderate heating, formamide yields a complete set of nucleic bases, acyclonucleosides, and favors both phosphorylations and transphosphorylations. Physico-chemical conditions exist in which formamide favors the stability of the phosphoester bonds in nucleic polymers more than that of the same bonds in monomers. This property establishes 'thermodynamic niches' in which the polymeric forms are favored. The hypothesis that these specific attributes of formamide allowed the onset of prebiotic chemical equilibria capable of Darwinian evolution is discussed.

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DOI: 10.1002/cbdv.200790059

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