STUDY OF EMBRYOTOXIC, TERATOGEN ACTIONS OF THE DRUG “BAKAGIN” FROM THE PAROTID SECRETES CENTRAL ASIAN GREEN TOAD BUFO VIRIDIS LAUR AND ITS EFFECT TO THE REPRODUCTIVE FUNCTION OF RATS
K. T. Agzamkhujaeva. Pharmaceutical SciencesSh. Ya. Mirzaakhmedov. Pharmaceutical SciencesR. A. YakubovaInstitute of Bioorganic Chemistry, Academy of Sciences Republic of UzbekistanМ. С. Ташмухамедов
ABI
Annotatsiya
The sum of bufadienolides, named as "Bakagin" obtained from the venom of the Central Asian green toad Bufo viridis Laur.The effect of the preparate to the embryotoxic, teratogenic activities and influence on the reproductive function was studied in laboratory rats.Obtained results show that, "Bakagin" when injected by intraperitoneally, in doses of 0.046 and 0.093 mg/kg, has not cause embryotoxic and teratogenic activities.A study of "Bakagin" on to reproductive function in white rats showed that in the studied doses it has not negative affect to the reproductive function of white outbred rats.
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