Sharh maqola

Slicing and dicing viruses: antiviral RNA interference in mammals

Pierre V. MaillardDivision of Infection and Immunity, University College London, London, UK [email protected] [email protected]Annemarthe G. van der VeenImmunobiology Laboratory, The Francis Crick Institute, London, UKEnzo Z. PoirierImmunobiology Laboratory, The Francis Crick Institute, London, UKCaetano Reis e SousaImmunobiology Laboratory, The Francis Crick Institute, London, UK [email protected] [email protected]

2019en

ABI

Annotatsiya

To protect against the harmful consequences of viral infections, organisms are equipped with sophisticated antiviral mechanisms, including cell-intrinsic means to restrict viral replication and propagation. Plant and invertebrate cells utilise mostly RNA interference (RNAi), an RNA-based mechanism, for cell-intrinsic immunity to viruses while vertebrates rely on the protein-based interferon (IFN)-driven innate immune system for the same purpose. The RNAi machinery is conserved in vertebrate cells, yet whether antiviral RNAi is still active in mammals and functionally relevant to mammalian antiviral defence is intensely debated. Here, we discuss cellular and viral factors that impact on antiviral RNAi and the contexts in which this system might be at play in mammalian resistance to viral infection.

Hali tarjima qilinmagan

Identifikatorlar

DOI: 10.15252/embj.2018100941

Iqtiboslar va manbalar

3 ta iqtibos0 ta foydalanilgan manba

Koʻrsatkichlar — AkademScholar