Antimicrobial Metabolites from the Paracel Islands Sponge <i>Agelas mauritiana</i>
Fan YangDepartment of Pharmacognosy
and National Center for Natural Products Research (NCNPR), School
of Pharmacy, The University of Mississippi, University, Mississippi 38677, United StatesMark T. HamannDepartment of Pharmacognosy
and National Center for Natural Products Research (NCNPR), School
of Pharmacy, The University of Mississippi, University, Mississippi 38677, United StatesYike ZouDepartment of Pharmacognosy
and National Center for Natural Products Research (NCNPR), School
of Pharmacy, The University of Mississippi, University, Mississippi 38677, United StatesMingyu ZhangLaboratory of Marine Drugs, Department
of Pharmacy, Changzheng Hospital, Second Military Medical University, Shanghai, 200003, People's Republic of ChinaXiaobin GongLaboratory of Marine Drugs, Department
of Pharmacy, Changzheng Hospital, Second Military Medical University, Shanghai, 200003, People's Republic of ChinaJianru XiaoDepartment of Bone Oncology, Changzheng Hospital, Second Military Medical University, Shanghai 200003,
People's Republic of ChinaWansheng ChenLaboratory of Marine Drugs, Department
of Pharmacy, Changzheng Hospital, Second Military Medical University, Shanghai, 200003, People's Republic of ChinaHou‐Wen LinLaboratory of Marine Drugs, Department
of Pharmacy, Changzheng Hospital, Second Military Medical University, Shanghai, 200003, People's Republic of China
2012en
ABI
Annotatsiya
Four new alkaloids, (-)-8'-oxo-agelasine D (2), ageloxime B (3), (+)-2-oxo-agelasidine C (4), and 4-bromo-N-(butoxymethyl)-1H-pyrrole-2-carboxamide (5), and the known compound (-)-ageloxime D (1) were isolated from the marine sponge Agelas mauritiana. Their chemical structures were established on the basis of spectroscopic analysis. Compounds 1 and 3 both showed antifungal activity against Cryptococcus neoformans and antileishmanial activity against Leishmania donovani in vitro. Compound 3 also exhibited antibacterial activity against Staphylococcus aureus and methicillin-resistant S. aureusin vitro.
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