Fragment-based approach to novel bioactive purine derivatives
В. П. КрасновRussian Academy of Sciences Ural Branch, Postovsky Institute of Organic Synthesis , 22/20 S.Kovalevskoy/Akademicheskaya St. , Yekaterinburg, 620108 , RussiaГалина Л. ЛевитRussian Academy of Sciences Ural Branch, Postovsky Institute of Organic Synthesis , 22/20 S.Kovalevskoy/Akademicheskaya St. , Yekaterinburg, 620108 , RussiaVera V. MusiyakRussian Academy of Sciences Ural Branch, Postovsky Institute of Organic Synthesis , 22/20 S.Kovalevskoy/Akademicheskaya St. , Yekaterinburg, 620108 , RussiaDmitry А. GruzdevRussian Academy of Sciences Ural Branch, Postovsky Institute of Organic Synthesis , 22/20 S.Kovalevskoy/Akademicheskaya St. , Yekaterinburg, 620108 , RussiaValery N. CharushinRussian Academy of Sciences Ural Branch, Postovsky Institute of Organic Synthesis , 22/20 S.Kovalevskoy/Akademicheskaya St. , Yekaterinburg, 620108 , Russia
2020en
ABI
Annotatsiya
Abstract Using purine as a scaffold, the methods for preparation of novel 2-aminopurine and purine derivatives substituted at position C 6 by the fragments of natural amino acids, short peptides, and N -heterocycles, including enantiopure ones, have been proposed. The methods for determination of the enantiomeric purity of the obtained chiral compounds have been developed. Conjugates exhibiting high antimycobacterial or anti-herpesvirus activity against both laboratory and multidrug-resistant strains were revealed among the obtained compounds.
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