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Sequence and genomic organization of GBV-C: A novel member of the flaviviridae associated with human non-A-E hepatitis

Thomas P. LearyVirus Discovery Group, Abbott Laboratories, North Chicago, Illinois, USAScott MuerhoffVirus Discovery Group, Experimental Biology Research, Abbott Laboratories, North Chicago, IllinoisJohn N. SimonsVirus Discovery Group, Experimental Biology Research, Abbott Laboratories, North Chicago, IllinoisTami J. Pilot-MatiasVirus Discovery Group, Experimental Biology Research, Abbott Laboratories, North Chicago, IllinoisJames C. ErkerVirus Discovery Group, Experimental Biology Research, Abbott Laboratories, North Chicago, IllinoisMichelle L. ChalmersVirus Discovery Group, Experimental Biology Research, Abbott Laboratories, North Chicago, IllinoisGeorge G. SchalauderVirus Discovery Group, Experimental Biology Research, Abbott Laboratories, North Chicago, IllinoisGeorge J. DawsonVirus Discovery Group, Experimental Biology Research, Abbott Laboratories, North Chicago, IllinoisSuresh M. DesaiVirus Discovery Group, Experimental Biology Research, Abbott Laboratories, North Chicago, IllinoisIsa K. MushahwarVirus Discovery Group, Experimental Biology Research, Abbott Laboratories, North Chicago, Illinois

1996en

ABI

Annotatsiya

Recently, sequences from a novel virus, termed GB virus C (GBV-C), were identified in serum from several patients with cryptogenic hepatitis. In the present study, the nucleotide sequence of this virus has been extended to near-genome length. GBV-C encodes a putative single large polyprotein in which the structural proteins are positioned at the N-terminal end, with the non-structural proteins located at the C-terminal end. Amino acid sequence analysis of this large polyprotein reveals the presence of protease, helicase, and replicase motifs. Sequence alignments of the polyprotein followed by phylogenetic analyses suggest that GBV-C is a member of the Flaviviridae, most closely related to the recently described GB virus A.

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Identifikatorlar

DOI: 10.1002/(sici)1096-9071(199601)48:1<60::aid-jmv10>3.0.co;2-a

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